Dark Dynamic Therapy: Photosensitization without Light Excitation Using Chemiluminescence Resonance Energy Transfer in a Dioxetane–Erythrosin B Conjugate
EM Digby, MT Tung, HN Kagalwala, LS Ryan… - ACS chemical …, 2022 - ACS Publications
Reactive oxygen species (eg, singlet oxygen) are the primary cytotoxic agents used in the
clinically approved technique photodynamic therapy (PDT). Although singlet oxygen has high …
clinically approved technique photodynamic therapy (PDT). Although singlet oxygen has high …
Selective detection of carboxylesterase 2 activity in cancer cells using an activity-based chemiluminescent probe
Carboxylesterase 2 (CES2) has crucial roles in both xenobiotic metabolism and formation of
pathogenic states including cancer. Thus, it is highly critical to monitor intracellular CES2 …
pathogenic states including cancer. Thus, it is highly critical to monitor intracellular CES2 …
Photocaged DNA-Binding Photosensitizer Enables Photocontrol of Nuclear Entry for Dual-Targeted Photodynamic Therapy
EM Digby, S Ayan, P Shrestha… - Journal of Medicinal …, 2022 - ACS Publications
Photodynamic therapy (PDT) is a clinically approved cancer treatment that requires a
photosensitizer (PS), light, and molecular oxygen─a combination which produces reactive oxygen …
photosensitizer (PS), light, and molecular oxygen─a combination which produces reactive oxygen …
An activatable photosensitizer targeting human NAD (P) H: quinone oxidoreductase 1
EM Digby, O Sadovski… - Chemistry–A European …, 2020 - Wiley Online Library
Human NAD(P)H: Quinone Oxidoreductase 1 (hNQO1) is an attractive enzyme for cancer
therapeutics due to its significant overexpression in tumors compared to healthy tissues. Its …
therapeutics due to its significant overexpression in tumors compared to healthy tissues. Its …
DNA directed damage using a brominated DAPI derivative
EM Digby, R Rana, M Nitz, AA Beharry - Chemical communications, 2019 - pubs.rsc.org
Photodynamic therapy (PDT) is a clinically approved cancer treatment that uses light, oxygen
and a photosensitizer to produce localized reactive oxygen species (ROS). Due to the …
and a photosensitizer to produce localized reactive oxygen species (ROS). Due to the …
Highly potent photoinactivation of bacteria using a water-soluble, cell-permeable, DNA-binding photosensitizer
EM Digby, T Ma, WR Zipfel, JN Milstein… - ACS Infectious …, 2021 - ACS Publications
Antimicrobial photodynamic therapy (APDT) employs a photosensitizer, light, and molecular
oxygen to treat infectious diseases via oxidative damage, with a low likelihood for the …
oxygen to treat infectious diseases via oxidative damage, with a low likelihood for the …
Correction to “Dark Dynamic Therapy: Photosensitization without Light Excitation Using Chemiluminescence Resonance Energy Transfer in a Dioxetane− Erythrosin B …
EM Digby, MT Tung, HN Kagalwala, LS Ryan… - ACS Chemical …, 2022 - ACS Publications
NMR spectra of CL-E1a (1H) and CL-E1 (1H and 13C) have been updated in the Supporting
Information and their purity by HPLC reported. These spectra are now from samples used …
Information and their purity by HPLC reported. These spectra are now from samples used …
The Development of Targeted Photosensitizers to Enhance the Efficacy and Selectivity of Photodynamic Therapy Against Cancer
EM Digby - 2023 - search.proquest.com
Photodynamic therapy is a clinically approved cancer therapeutic that uses a photosensitizer,
light, and oxygen to produce reactive oxygen species. The accumulation of reactive …
light, and oxygen to produce reactive oxygen species. The accumulation of reactive …
Monocytosis is a biomarker of severity in inflammatory bowel disease: Analysis of a 6-year prospective natural history registry
…, D Babichenko, G Tang, M Dunn… - Inflammatory bowel …, 2022 - academic.oup.com
Background Inflammatory bowel disease (IBD) is associated with alterations of the innate
and adaptive immune systems. Monocytes respond to inflammation and infection, yet the …
and adaptive immune systems. Monocytes respond to inflammation and infection, yet the …
[PDF][PDF] Made How
L Hall - 2013 - lamc-media.s3.amazonaws.com
A couple of months ago, Angelenos were treated to a concert by a chamber ensemble known
as The Golden Bridge (whose singers include some members of the Los Angeles Master …
as The Golden Bridge (whose singers include some members of the Los Angeles Master …