Integrin α M β 2 (Mac-1, CD11b/CD18) is a noncovalently linked heterodimer of α M and β 2
subunits on the surface of leukocytes, where it plays a pivotal role in the adhesion and …

Leukocyte-derived microparticles (MPs) are markers of cardiovascular diseases and contribute
to pathogenesis by their interaction with various cell types. The presence and activation …

Reduced levels of kindlin-2 (K2) in endothelial cells derived from K2 +/− mice or C2C12
myoblastoid cells treated with K2 siRNA showed disorganization of their actin cytoskeleton and …

Rationale: Thrombospondin (TSP)-4 is an extracellular protein that has been linked to several
cardiovascular pathologies. However, a role for TSP-4 in vascular wall biology remains …

Macrophage accumulation is a critical step during development of chronic inflammation,
initiating progression of many devastating diseases. Leukocyte-specific integrin α D β 2 (CD11d/…

Kindlin-2, a widely distributed cytoskeletal protein, has been implicated in integrin activation,
and its absence is embryonically lethal in mice and causes severe developmental defects …

Interplay between tumor cells and host cells in the tumor microenvironment dictates the
development of all cancers. In breast cancer, malignant cells educate host macrophages to …

The role of integrins in angiogenesis has been demonstrated to include, in addition to cell
adhesion and mechanotransduction, specific signaling functions. The importance of integrin …

Candida albicans is a common opportunistic fungal pathogen and is the leading cause of
invasive fungal disease in immunocompromised individuals. The induction of cell-mediated …

The FERM domain containing protein Kindlin-3 has been recognized as a major regulator of
integrin function in hematopoietic cells, but its role in neoplasia is totally unknown. We have …