Structure-activity relationships of mitochondria-targeted tetrapeptide pharmacological compounds

W Mitchell, JD Tamucci, EL Ng, S Liu, AV Birk… - Elife, 2022 - elifesciences.org
Mitochondria play a central role in metabolic homeostasis, and dysfunction of this organelle
underpins the etiology of many heritable and aging-related diseases. Tetrapeptides with …

Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

…, AP Doumatey, S Du, Q Duan, KU Eckardt, LS Emery… - Nature …, 2022 - nature.com
We assembled an ancestrally diverse collection of genome-wide association studies (GWAS)
of type 2 diabetes (T2D) in 180,834 affected individuals and 1,159,055 controls (48.9% non…

Author Spotlight: Decoding Mitochondrial Aging

EL Ng, AL Reed, CB O'Connell, NN Alder - JoVE (Journal of Visualized …, 2023 - jove.com
Mitochondria play many essential roles in the cell, including energy production, regulation
of Ca2+ homeostasis, lipid biosynthesis, and production of reactive oxygen species (ROS). …

Trans-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

…, AP Doumatey, S Du, Q Duan, KU Eckardt, LS Emery… - MedRxiv, 2020 - medrxiv.org
We assembled an ancestrally diverse collection of genome-wide association studies of type
2 diabetes (T2D) in 180,834 cases and 1,159,055 controls (48.9% non-European descent). …

Structure-Activity Relationships in the Design of Mitochondria-Targeted Peptide Therapeutics

W Mitchell, JD Tamucci, EL Ng, S Liu, HH Szeto… - bioRxiv, 2021 - biorxiv.org
Mitochondria play a central role in metabolic homeostasis; hence, dysfunction of this
organelle underpins the etiology of many heritable and aging-related diseases. Mitochondria-…

Cardiovascular toxicity and titin cross-reactivity of affinity-enhanced T cells in myeloma and melanoma

…, BL Levine, L Emery, L Litzky… - Blood, The Journal …, 2013 - ashpublications.org
… were elevated: troponin I was recorded at 54.4 ng/mL (normal range, 0.00 to 0.24 ng/mL)
and creatinine kinase MB at 65 ng/mL (normal range, 0 to 7 ng/mL). Within 30 minutes, he …

Reference ranges for newer thyroid function tests in premature infants

LM Adams, JR Emery, SJ Clark, EI Carlton… - The Journal of …, 1995 - Elsevier
… Two reference ranges for free T 4 were determined, one for 25 to 30 weeks (6.4 to 42.5
pmol/L [0.5 to 3.3 ng/dl]) and one for 31 to 36 weeks (16.7 to 60.5 pmol/L [1.3 to 4.7 ng/dl]). The …

[PDF][PDF] Associations of mitochondrial and nuclear mitochondrial variants and genes with seven metabolic traits

…, TS Ahluwalia, R De Mutsert, LS Emery… - The American Journal of …, 2019 - cell.com
Mitochondria (MT), the major site of cellular energy production, are under dual genetic control
by 37 mitochondrial DNA (mtDNA) genes and numerous nuclear genes (MT-nDNA). In the …

Direct space-charge calculation in elegant and its application to the ilc damping ring

…, M Borland, L Emery, Y Wang, KY Ng - 2007 IEEE Particle …, 2007 - ieeexplore.ieee.org
A direct space-charge force model has been implemented in the tracking code elegant [1].
The user can simulate transverse space-charge effects by inserting space- charge elements …

Randomized controlled trial of rituximab and cost‐effectiveness analysis in treating fatigue and oral dryness in primary Sjögren's syndrome

…, JL O'Dwyer, P Emery, C Pitzalis, WF Ng… - Arthritis & …, 2017 - Wiley Online Library
Objective To investigate whether rituximab, an anti–B cell therapy, improves symptoms of
fatigue and oral dryness in patients with primary Sjögren's syndrome (SS). Methods We …