The electromechanical function of the heart involves complex, coordinated activity over time
and space. Life-threatening cardiac arrhythmias arise from asynchrony in these space–time …

The improvement of preclinical cardiotoxicity testing, discovery of new ion-channel-targeted
drugs, and phenotyping and use of stem cell-derived cardiomyocytes and other biologics all …

Optogenetics is an emerging technology for optical interrogation and control of biological
function with high specificity and high spatiotemporal resolution. Mammalian cells and tissues …

Optogenetics has emerged as an alternative method for electrical control of the heart, where
illumination is used to elicit a bioelectric response in tissue modified to express …

Background— Phosphoinositide 3-kinase (PI3K) p110α plays a key role in insulin action and
tumorigenesis. Myocyte contraction is initiated by an inward Ca 2+ current (I Ca,L ) through …

Cardiac tissue is an excitable system that can support complex spatiotemporal dynamics,
including instabilities (arrhythmias) with lethal consequences. While over the last two decades …

The structural and functional effects of fine-textured matrices with sub-micron features on
the growth of cardiac myocytes were examined. Electrospinning was used to fabricate …

Optogenetic techniques have been developed to allow control over the activity of selected
cells within a highly heterogeneous tissue, using a combination of genetic engineering and …

Cellulose and its derivatives have been successfully employed as biomaterials in various
applications, including dialysis membranes, diffusion-limiting membranes in biosensors, in …

Background— After the recent cloning of light-sensitive ion channels and their expression in
mammalian cells, a new field, optogenetics, emerged in neuroscience, allowing for precise …