A complete understanding of how exposure to environmental substances promotes cancer
formation is lacking. More than 70 years ago, tumorigenesis was proposed to occur in a two-…

We present the molecular landscape of pediatric acute myeloid leukemia (AML) and
characterize nearly 1,000 participants in Children's Oncology Group (COG) AML trials. The COG–…

Lung cancer is the leading cause of cancer-associated mortality worldwide 1 . Here we
analysed 1,644 tumour regions sampled at surgery or during follow-up from the first 421 patients …

B cells are frequently found in the margins of solid tumours as organized follicles in ectopic
lymphoid organs called tertiary lymphoid structures (TLS) 1 , 2 . Although TLS have been …

Circulating tumour DNA (ctDNA) can be used to detect and profile residual tumour cells
persisting after curative intent therapy 1 . The study of large patient cohorts incorporating …

Diffuse large B-cell lymphoma (DLBCL) is a genetically heterogeneous cancer composed of
at least 2 molecular subtypes that differ in gene expression and distribution of mutations. …

Metastatic disease is responsible for the majority of cancer-related deaths 1 . We report the
longitudinal evolutionary analysis of 126 non-small cell lung cancer (NSCLC) tumours from …

Chromosomal instability in cancer consists of dynamic changes to the number and structure
of chromosomes 1 , 2 . The resulting diversity in somatic copy number alterations (SCNAs) …

Intratumour heterogeneity (ITH) fuels lung cancer evolution, which leads to immune evasion
and resistance to therapy 1 . Here, using paired whole-exome and RNA sequencing data, …

Lung adenocarcinomas (LUADs) display a broad histological spectrum from low-grade
lepidic tumors through to mid-grade acinar and papillary and high-grade solid, cribriform and …