Functional interplay between tumour cells and their neoplastic extracellular matrix plays a
decisive role in malignant progression of carcinomas. Here we provide a comprehensive data …

Luminal B breast cancers represent a fraction of oestrogen receptor (ER)‐positive tumours
associated with poor recurrence‐free and disease‐specific survival in all adjuvant systemic …

The RLTPR cytosolic protein, also known as CARMIL2, is essential for CD28 co-stimulation
in mice, but its importance in human T cells and mode of action remain elusive. Here, using …

The heat shock protein 27 (Hsp27) has emerged as a principal factor of the castration-resistant
prostate cancer (CRPC) progression. Also, an antisense oligonucleotide (ASO) against …

Background Breast cancer stem cells (BCSCs) have been recognized as playing a major
role in various aspects of breast cancer biology. To identify specific biomarkers of BCSCs, we …

An affinity purification strategy was developed to characterize human proteasome complexes
diversity as well as endogenous proteasome-interacting proteins (PIPs). This single step …

Oral-facial-digital (OFD) syndromes are rare heterogeneous disorders characterized by the
association of abnormalities of the face, the oral cavity and the extremities, some due to …

Background Mutations in the Planar Cell Polarity (PCP) core gene Vangl2 cause the most
severe neural tube defects (NTD) in mice and humans. Genetic studies show that the Vangl2 …

Formins constitute a large family of proteins that regulate the dynamics and organization of
both the actin and microtubule cytoskeletons. Previously we showed that the formin mDia1 …

Pancreatic ductal adenocarcinoma (PDAC) is a very aggressive malignancy characterized
by an excessive resistance to all known anticancer therapies, a still largely elusive …