[PDF][PDF] Regional heterogeneity in gene expression, regulation, and coherence in the frontal cortex and hippocampus across development and schizophrenia
L Collado-Torres, EE Burke, A Peterson, JH Shin… - Neuron, 2019 - cell.com
The hippocampus formation, although prominently implicated in schizophrenia pathogenesis,
has been overlooked in large-scale genomics efforts in the schizophrenic brain. We …
has been overlooked in large-scale genomics efforts in the schizophrenic brain. We …
Analysis of the caudate nucleus transcriptome in individuals with schizophrenia highlights effects of antipsychotics and new risk genes
Most studies of gene expression in the brains of individuals with schizophrenia have focused
on cortical regions, but subcortical nuclei such as the striatum are prominently implicated in …
on cortical regions, but subcortical nuclei such as the striatum are prominently implicated in …
Amygdala and anterior cingulate transcriptomes from individuals with bipolar disorder reveal downregulated neuroimmune and synaptic pathways
Recent genetic studies have identified variants associated with bipolar disorder (BD), but it
remains unclear how brain gene expression is altered in BD and how genetic risk for BD may …
remains unclear how brain gene expression is altered in BD and how genetic risk for BD may …
[HTML][HTML] Dissecting transcriptomic signatures of neuronal differentiation and maturation using iPSCs
EE Burke, JG Chenoweth, JH Shin… - Nature …, 2020 - nature.com
Human induced pluripotent stem cells (hiPSCs) are a powerful model of neural differentiation
and maturation. We present a hiPSC transcriptomics resource on corticogenesis from 5 …
and maturation. We present a hiPSC transcriptomics resource on corticogenesis from 5 …
Profiling gene expression in the human dentate gyrus granule cell layer reveals insights into schizophrenia and its genetic risk
…, T Saito, L Blanpain, J Ukaigwe, EE Burke… - Nature …, 2020 - nature.com
Specific cell populations may have unique contributions to schizophrenia but may be missed
in studies of homogenate tissue. Here laser capture microdissection followed by RNA …
in studies of homogenate tissue. Here laser capture microdissection followed by RNA …
A myelin-related transcriptomic profile is shared by Pitt–Hopkins syndrome models and human autism spectrum disorder
Autism spectrum disorder (ASD) is genetically heterogeneous with convergent
symptomatology, suggesting common dysregulated pathways. In this study, we analyzed brain …
symptomatology, suggesting common dysregulated pathways. In this study, we analyzed brain …
[HTML][HTML] Comprehensive assessment of multiple biases in small RNA sequencing reveals significant differences in the performance of widely used methods
C Wright, A Rajpurohit, EE Burke, C Williams… - BMC genomics, 2019 - Springer
Background RNA sequencing offers advantages over other quantification methods for
microRNA (miRNA), yet numerous biases make reliable quantification challenging. Previous …
microRNA (miRNA), yet numerous biases make reliable quantification challenging. Previous …
[HTML][HTML] Divergent neuronal DNA methylation patterns across human cortical development reveal critical periods and a unique role of CpH methylation
Background DNA methylation (DNAm) is a critical regulator of both development and
cellular identity and shows unique patterns in neurons. To better characterize maturational …
cellular identity and shows unique patterns in neurons. To better characterize maturational …
[HTML][HTML] The effect of platelet-rich plasma on osseous healing in dogs undergoing high tibial osteotomy
SP Franklin, EE Burke, SP Holmes - PLoS One, 2017 - journals.plos.org
Objectives The purpose of this study was to investigate whether platelet-rich plasma (PRP)
enhances osseous healing in conjunction with a high tibial osteotomy in dogs. Study design …
enhances osseous healing in conjunction with a high tibial osteotomy in dogs. Study design …
US Catholic bishops' silence and denialism on climate change
S Danielsen, DR DiLeo, EE Burke - Environmental Research …, 2021 - iopscience.iop.org
The Catholic Church recognizes climate change as a moral issue, has called for social action,
and has the institutional potential to meaningfully address climate change. Many hoped …
and has the institutional potential to meaningfully address climate change. Many hoped …