Single-cell technologies are emerging as powerful tools for cancer research. These technologies
characterize the molecular state of each cell within a tumor, enabling new exploration …

Rationale: The advent of precision treatment for cystic fibrosis using small-molecule therapeutics
has created a need to estimate potential clinical improvements attributable to increases …

… Emily F. Davis-Marcisak … F, Gene weights for the genes most associated with each of the
CoGAPS patterns that corresponded with cellular partitions. G, Proportion of cells in each group …

Background Identifying potential resistance mechanisms while tumour cells still respond to
therapy is critical to delay acquired resistance. Methods We generated the first …

Elucidating the functional consequence of molecular defects underlying genetic diseases
enables appropriate design of therapeutic options. Treatment of cystic fibrosis (CF) is an …

Background Tumor response to therapy is affected by both the cell types and the cell states
present in the tumor microenvironment. This is true for many cancer treatments, including …

… Emily F. Davis-Marcisak … Administrative, technical, or material support (ie, reporting or
organizing data, constructing databases): EF Davis-Marcisak, EJ Fertig …

Biological systems are fundamentally multi-scale, with mostly uncharacterized molecular
pathways, cellular actions, and cellular communities that collectively give rise to their function. …

Immune checkpoint-inhibitory antibodies (ICIs) are wellestablished immunotherapies.
Despite this, the impact of ICI therapy on non-T cell intratumoral immune cells is ill-defined, …

The original version of this Article contained an error in Fig. 1 b. The figure and legend
mislabelled SCC1 as blue and SCC25 as orange, where it should have labelled SCC1 as orange …