Frequent loss of heterozygosity in CRISPR-Cas9–edited early human embryos

…, N Kubikova, E Hardman… - Proceedings of the …, 2021 - National Acad Sciences
CRISPR-Cas9 genome editing is a promising technique for clinical applications, such as the
correction of disease-associated alleles in somatic cells. The use of this approach has also …

[HTML][HTML] Maternal iron deficiency perturbs embryonic cardiovascular development in mice

…, JJ Miller, EM Stuart, M Wolna, E Hardman… - Nature …, 2021 - nature.com
Congenital heart disease (CHD) is the most common class of human birth defects, with a
prevalence of 0.9% of births. However, two-thirds of cases have an unknown cause, and many …

[HTML][HTML] Highly variable penetrance of abnormal phenotypes in embryonic lethal knockout mice

…, L Reissig, J Rose, D Szumska, E Hardman… - Wellcome open …, 2016 - ncbi.nlm.nih.gov
Background: Identifying genes that are essential for mouse embryonic development and
survival through term is a powerful and unbiased way to discover possible genetic determinants …

[PDF][PDF] The reefs of Mauritius

JR Turner, E Hardman, R Klaus, I Fagoonee… - Coral reef degradation …, 2000 - cordio.org
The study investigated whether the coral reefs of Mauritius had suffered a mass bleaching
event during 1998 as had been reported for other Indian Ocean reefs. Seasurface …

A sea surface temperature reconstruction for the southern Indian Ocean trade wind belt from corals in Rodrigues Island (19 S, 63 E)

…, M Pfeiffer, JA Wassenburg, E Hardman… - …, 2016 - bg.copernicus.org
The western Indian Ocean has been warming rapidly over recent decades, causing a greater
number of extreme climatic events. It is therefore of paramount importance to improve our …

The extent of coral bleaching in Rodrigues, 2002

ER Hardman, M Sabrina Meunier, JR Turner… - Journal of Natural …, 2004 - Taylor & Francis
The reefs of Rodrigues were some of the few reef areas in the Indian Ocean to escape the
mass coral bleaching event of 1997–1998. However, during the last 2 weeks of February …

Movement of sonically tagged bluespine unicornfish, Naso unicornis, in relation to marine reserve boundaries in Rodrigues, western Indian Ocean

E Hardman, JM Green… - Aquatic Conservation …, 2010 - Wiley Online Library
The lagoon fishery of Rodrigues has considerable socio‐economic importance; however,
catches have declined by 50% in recent years. The bluespine unicornfish, Naso unicornis (…

[PDF][PDF] The impacts of coral bleaching in Rodrigues, Western Indian Ocean

ER HARdmAN, NS STAmpfLI, L Hunt… - Atoll Research …, 2007 - repository.si.edu
Rapid assessments of the degree of coral bleaching were carried out at 22 sites around the
coast of Rodrigues during March-april 2005 and april-May 2006. during 2005, coral …

The Col4a2em1(IMPC)Wtsi mouse line: lessons from the Deciphering the Mechanisms of Developmental Disorders program

…, JL Lane, F Prin, R Wilson, E Hardman… - Biology …, 2019 - journals.biologists.com
The Deciphering the Mechanisms of Developmental Disorders (DMDD) program uses a
systematic and standardised approach to characterise the phenotype of embryos stemming from …

[HTML][HTML] Predicting neurosurgical referral outcomes in patients with chronic subdural hematomas using machine learning algorithms–A multi-center feasibility study

…, ZR Almansoor, XT Chai, E Hardman… - Surgical Neurology …, 2023 - ncbi.nlm.nih.gov
Background: Chronic subdural hematoma (CSDH) incidence and referral rates to neurosurgery
are increasing. Accurate and automated evidence-based referral decision-support tools …