Human intestinal organoids (HIOs) derived from pluripotent stem cells provide a valuable
model for investigating human intestinal organogenesis and physiology, but they lack the …

Organs are composed of diverse cell types that traverse transient states during organogenesis.
To interrogate this diversity during human development, we generate a single-cell …

During development, distinct progenitors contribute to the nephrons versus the ureteric
epithelium of the kidney. Indeed, previous human pluripotent stem-cell-derived models of kidney …

Human pluripotent stem cell (hPSC)-derived intestinal organoids (HIOs) lack some cellular
populations found in the native organ, including vasculature. Using single-cell RNA …

Bud tip progenitor cells give rise to all murine lung epithelial lineages and have been
described in the developing human lung; however, the mechanisms controlling human bud tip …

Using scRNA-seq and microscopy, we describe a cell that is enriched in the lower airways
of the developing human lung and identified by the unique coexpression of SCGB3A2/SFTPB/…

The human intestinal stem cell niche supports self-renewal and epithelial function, but little
is known about its development. We used single-cell mRNA sequencing with in situ …

Organoids are complex three-dimensional in vitro organ-like model systems. Human
organoids, which are derived from human pluripotent stem cells or primary human donor tissue, …

Pluripotent-stem-cell-derived human intestinal organoids (HIOs) model some aspects of
intestinal development and disease, but current culture methods do not fully recapitulate the …

Bud tip progenitors (BTPs) in the developing lung give rise to all epithelial cell types found in
the airways and alveoli. This work aimed to develop an iPSC organoid model enriched with …