Psoriasis is a common inflammatory disorder of the skin and other organs. We have determined
that mutations in CARD14, encoding a nuclear factor of kappa light chain enhancer in B …

Background Trichotillomania (TTM) is a difficult‐to‐treat psychiatric condition with no first‐line
medications approved by the Food and Drug Administration. Individuals with TTM often …

The American College of Medical Genetics and Genomics (ACMG) recommends that clinical
sequencing laboratories return secondary findings in 56 genes associated with medically …

Epidemiological studies have provided varying prevalence estimates of trichotillomania (TTM)
and other hair-pulling behaviors. We performed a systematic review and meta-analysis to …

Background Obsessive-compulsive disorder (OCD) is a debilitating neuropsychiatric disorder
with a genetic risk component, yet identification of high-confidence risk genes has been …

Background Genome‐wide association ( GWA ) studies have led to a paradigm shift in how
researchers study the genetics underlying disease. Many GWA studies are now publicly …

The common nonsynonymous variant rs16969968 in the α5 nicotinic receptor subunit gene (CHRNA5)
is the strongest genetic risk factor for nicotine dependence in European …

Epidemiological studies of excoriation disorder have reported different prevalence estimates
for this condition, limiting our understanding of its public health impact. We performed a …

Trichotillomania (hair-pulling disorder) and excoriation (skin-picking) disorder are body-focused
repetitive behaviors, which often first present in adolescence and cause distress and …

Imputation, the process of inferring genotypes for untyped variants, is used to identify and
refine genetic association findings. Inaccuracies in imputed data can distort the observed …