Significance: Fibrosis is the endpoint of chronic disease in multiple organs, including the skin,
heart, lungs, intestine, liver, and kidneys. Pathologic accumulation of fibrotic tissue results …

Idiopathic pulmonary fibrosis (IPF) is a life-threatening progressive lung disorder with
limited therapeutic options. While interleukin-10 (IL-10) is a potent anti-inflammatory and anti-…

Objective: While tissue injury and repair are known to involve adaptive immunity, the profile
of lymphocytes involved and their contribution to dermal scarring remain unclear. We …

Endothelial progenitor cells (EPCs) contribute to de novo angiogenesis, tissue regeneration,
and remodeling. Interleukin 10 (IL‐10), an anti‐inflammatory cytokine that primarily signals …

OBJECTIVE To discuss what is known about the wound milieu in premature and full-term
neonates, including the unique challenges pediatric clinicians face, the therapies that have …

Background Central venous catheter (CVC) use is common in the management of critically
ill children, especially those with congenital heart disease. CVCs are known to augment the …

Renal fibrosis features exaggerated inflammation, extracellular matrix (ECM) deposition,
and peritubular capillary loss. We previously showed that IL-10 stimulates high–molecular …

Background Congenital lung malformations (CLMs) have a variable natural history: some
patients require urgent perinatal surgical intervention (UPSI) and others remain asymptomatic. …

Bronchopulmonary dysplasia (BPD) is a chronic lung disease of the neonate characterized
by impaired alveolarization and vascular growth. BPD is more common in premature male …

Background The benefits to early repair (< 72 h postcannulation) of infants with congenital
diaphragmatic hernia (CDH) on extracorporeal membrane oxygenation (ECMO) are …