Genetic screens using pooled CRISPR-based approaches are scalable and inexpensive,
but restricted to standard readouts, including survival, proliferation and sortable markers. …

INTRODUCTION Current views of human evolution, as supported by the fossil record,
indicate that many hominin lineage branches arose, but only one survived to the present. …

Two mycobacteriophages were administered intravenously to a male with treatment-refractory
Mycobacterium abscessus pulmonary infection and severe cystic fibrosis lung disease. …

… Emily Wheeler). We thank Meghan Midgley, Zach Brown, Nate Barnett, Tyler Klingenberger
and Daniel O’Conner for field and lab assistance, and Edward Brzostek, Matt Craig, Meghan …

RNA binding proteins ( RBPs ) play key roles in determining cellular behavior by manipulating
the processing of target RNAs . Robust methods are required to detect the numerous …

Ecological overlap may increase the risks of microbial exchange between humans and wild
non-human primates. Escherichia coli bacteria were collected from chimpanzees and …

Herbivorous reptiles depend on complex gut microbial communities to effectively degrade
dietary polysaccharides. The composition of these fermentative communities may vary based …

Background A critical step in uncovering rules of RNA processing is to study the in vivo
regulatory networks of RNA binding proteins (RBPs). Crosslinking and immunoprecipitation (CLIP…

Infrastructure is usually defined as all elements of interrelated systems that provide goods
and services essential to enabling, sustaining or enhancing societal living conditions. …

Recent studies have characterized the extensive somatic alterations that arise during cancer.
However, the somatic evolution of a tumor may be significantly affected by inherited …