RECQ-like helicases Sgs1 and BLM regulate R-loop–associated genome instability
EYC Chang, CA Novoa, MJ Aristizabal… - Journal of Cell …, 2017 - rupress.org
Sgs1, the orthologue of human Bloom’s syndrome helicase BLM, is a yeast DNA helicase
functioning in DNA replication and repair. We show that SGS1 loss increases R-loop …
functioning in DNA replication and repair. We show that SGS1 loss increases R-loop …
[HTML][HTML] ARID1A regulates R-loop associated DNA replication stress
S Tsai, LA Fournier, EY Chang, JP Wells… - PLoS …, 2021 - journals.plos.org
ARID1A is a core DNA-binding subunit of the BAF chromatin remodeling complex, and is lost
in up to 7% of all cancers. The frequency of ARID1A loss increases in certain cancer types, …
in up to 7% of all cancers. The frequency of ARID1A loss increases in certain cancer types, …
[HTML][HTML] MRE11-RAD50-NBS1 promotes Fanconi Anemia R-loop suppression at transcription–replication conflicts
EYC Chang, S Tsai, MJ Aristizabal, JP Wells… - Nature …, 2019 - nature.com
Ectopic R-loop accumulation causes DNA replication stress and genome instability. To avoid
these outcomes, cells possess a range of anti-R-loop mechanisms, including RNaseH that …
these outcomes, cells possess a range of anti-R-loop mechanisms, including RNaseH that …
[HTML][HTML] Replication fork protection factors controlling R-loop bypass and suppression
EYC Chang, PC Stirling - Genes, 2017 - mdpi.com
Replication–transcription conflicts have been a well-studied source of genome instability for
many years and have frequently been linked to defects in RNA processing. However, recent …
many years and have frequently been linked to defects in RNA processing. However, recent …
[HTML][HTML] Recent progress in the genetics of diabetic microvascular complications
YC Chang, EYC Chang, LM Chuang - World journal of diabetes, 2015 - ncbi.nlm.nih.gov
Diabetic complications including diabetic nephropathy, retinopathy, and neuropathy are as
major causes of morbidity and mortality in diabetes individuals worldwide and current …
major causes of morbidity and mortality in diabetes individuals worldwide and current …
[HTML][HTML] RAD18 opposes transcription-associated genome instability through FANCD2 recruitment
JP Wells, EYC Chang, L Dinatto, J White, S Ryall… - PLoS …, 2022 - journals.plos.org
DNA replication is a vulnerable time for genome stability maintenance. Intrinsic stressors, as
well as oncogenic stress, can challenge replication by fostering conflicts with transcription …
well as oncogenic stress, can challenge replication by fostering conflicts with transcription …
[HTML][HTML] Inhibition of Prostaglandin Reductase 2, a Putative Oncogene Overexpressed in Human Pancreatic Adenocarcinoma, Induces Oxidative Stress-Mediated Cell Death Involving xCT …
EYC Chang, YC Chang, CT Shun, YW Tien, SH Tsai… - PLoS …, 2016 - journals.plos.org
Prostaglandin reductase 2 (PTGR2) is the enzyme that catalyzes 15-keto-PGE 2 , an
endogenous PPARγ ligand, into 13,14-dihydro-15-keto-PGE 2 . Previously, we have reported a …
endogenous PPARγ ligand, into 13,14-dihydro-15-keto-PGE 2 . Previously, we have reported a …
[HTML][HTML] Prostaglandin reductase 2 modulates ROS-mediated cell death and tumor transformation of gastric cancer cells and is associated with higher mortality in …
EYC Chang, SH Tsai, CT Shun, SW Hee… - The American journal of …, 2012 - Elsevier
Various prostanoids and peroxisome proliferator-activated receptor γ (PPARγ) ligands play
an important role in gastric cancer. Previously, we demonstrated that prostaglandin …
an important role in gastric cancer. Previously, we demonstrated that prostaglandin …
Knockdown of RyR3 enhances adiponectin expression through an atf3-dependent pathway
SH Tsai, EYC Chang, YC Chang, SW Hee… - …, 2013 - academic.oup.com
Adiponectin is an important adipose-specific protein, which possesses insulin (INS)-sensitizing,
antiinflammatory, and antiatherosclerotic functions. However, its regulation remains …
antiinflammatory, and antiatherosclerotic functions. However, its regulation remains …
Cytoskeletal protein vimentin interacts with and regulates peroxisome proliferator‐activated receptor gamma via a proteasomal degradation process
YC Tsai, SH Tsai, EYC Chang, SW Hee… - Journal of Cellular …, 2013 - Wiley Online Library
Peroxisome proliferators‐activated receptor gamma (PPARγ) receptor is a transcription
factor that is located in and functions primarily in the nucleus. PPARγ is exported from the …
factor that is located in and functions primarily in the nucleus. PPARγ is exported from the …