Cervical cancer is caused by human papillomavirus infection. Most human papillomavirus
infection is harmless and clears spontaneously but persistent infection with high-risk human …

PURPOSE The randomized Adjuvant Chemoradiotherapy Versus Radiotherapy Alone in
Women With High-Risk Endometrial Cancer (PORTEC-3) trial investigated the benefit of …

Purpose Pathogenic variants affecting MLH1, MSH2, MSH6, and PMS2 cause Lynch syndrome
and result in different but imprecisely known cancer risks. This study aimed to provide …

This study aimed to investigate whether molecular analysis can be used to refine risk
assessment, direct adjuvant therapy, and identify actionable alterations in high-risk endometrial …

Endometrial cancer is the most common gynaecological cancer in high income countries
and its incidence is rising globally. Although an ageing population and fewer benign …

Background: Body mass index (BMI) is a risk factor for endometrial cancer. We quantified
the risk and investigated whether the association differed by use of hormone replacement …

Background Risk-assessment of endometrial cancer (EC) is based on clinicopathological
factors and molecular subgroup. It is unclear whether adding hormone receptor expression, …

… Author links open overlay panel Emma J. Crosbie PhD 1 2 3 , Neil AJ Ryan MBChB 1 4 ,
Mark J. Arends PhD 5 , Tjalling Bosse PhD 6 , John Burn MD 7 , Joanna M. Cornes BSc 8 , …

Background Surgical site infection (SSI) rates vary from 1% to 5% in the month following
surgery. Due to the large number of surgical procedures conducted annually, the costs of these …

BACKGROUND Metformin is an effective oral anti-hyperglycaemic drug used as first-line
medical treatment for type 2 diabetes. It improves systemic hyperglycaemia by reducing hepatic …