Ubiquitin ligases (E3s) embedded in the endoplasmic reticulum (ER) membrane regulate
essential cellular activities including protein quality control, calcium flux, and sterol …

Despite the known importance of zinc for human immunity, molecular insights into its roles
have remained limited. Here we report a novel autosomal recessive disease characterized by …

Actively maintained close appositions between organelle membranes, also known as contact
sites, enable the efficient transfer of biomolecules between cellular compartments. Several …

The mammalian ubiquitin ligase Hrd1 is the central component of a complex facilitating
degradation of misfolded proteins during the ubiquitin–proteasome-dependent process of ER-…

Mitochondrial functions are tightly regulated by nuclear activity, requiring extensive
communication between these organelles. One way by which organelles can communicate is …

Identification of both stable and transient interactions is essential for understanding protein
function and regulation. While assessing stable interactions is more straightforward, …

The evolution of eukaryotic genomes has been propelled by a series of gene duplication
events, leading to an expansion in new functions and pathways. While duplicate genes may …

Membrane contact sites are molecular bridges between organelles that are sustained by
tethering proteins and enable organelle communication. The endoplasmic reticulum (ER) …

The mammalian ubiquitin ligase Hrd1 is the central component of a complex facilitating
degradation of misfolded proteins during the ubiquitin–proteasome-dependent process of ER-…

… How to cite: FENECH, EMMA,JOANNE (2014) Dissection of Prosurvival and Apoptotic
Signalling By Human IRE1α, Durham theses, Durham University. Available at … Emma J Fenech …