Chimeric antigen receptor (CAR) technology can be used to engineer the antigen specificity
of regulatory T cells (Tregs) and improve their potency as an adoptive cell therapy in …

Antigen-specific regulatory T cells (T regs ) engineered with chimeric antigen receptors (CARs)
are a potent immunosuppressive cellular therapy in multiple disease models and could …

Background. Type 1 diabetes is an autoimmune disease characterized by T-cell–mediated
destruction of pancreatic beta-cells. Islet transplantation is an effective therapy, but its …

Antigen-specific regulatory T cells (Tregs) engineered with chimeric antigen receptor (CARs)
are a potent immunosuppressive cellular therapy in multiple disease models. To date the …

The Regulator of Capsule Synthesis (Rcs) phosphorelay pathway regulates the expression
of genes necessary for biofilm formation and stress response within Enterobacteriaceae. …

Microbial communities and their associated bioactive compounds 1 , 2 – 3 are often disrupted
in conditions such as the inflammatory bowel diseases (IBD) 4 . However, even in well-…

We have isolated a soluble cytochrome from Shewanella oneidensis that contains eight
covalently attached heme groups and determined its crystal structure. One of these hemes …

In type 1 diabetes (T1D), autoreactive T cells mediate the destruction of insulin-producing
islet beta cells, leading to an inability to regulate blood glucose. If the patient cannot control …

bioBakery is a meta’omic analysis environment and collection of individual software tools with
the capacity to process raw shotgun sequencing data into actionable microbial community …

This mixed-methods study focuses on the evidence of the health impacts of climate change
on populations affected by humanitarian crises, presented from the perspective of Médecins …