In a large proportion of cancer patients, CD8 T cells are excluded from the vicinity of cancer
cells. The inability of CD8 T cells to reach tumor cells is considered an important mechanism …

Macrophage infiltration is a hallmark of solid cancers, and overall macrophage infiltration
correlates with lower patient survival and resistance to therapy. Tumor-associated …

It is well established that tumor-associated macrophages (TAM) found in most advanced
tumors have a pro-tumoral role. In this context, TAM limit the activity of tumor-infiltrating …

Genetics studies have identified the gene for the high-affinity IgE receptor (FcεRI) β subunit
as a candidate gene for atopy. We have shown that β is an intrinsic signaling amplifier …

Appropriate localization and migration of T cells is a prerequisite for antitumor immune
surveillance. Studies using fixed tumor samples from human patients have shown that T cells …

Only a fraction of cancer patients benefits from immune checkpoint inhibitors. This may be
partly due to the dense extracellular matrix (ECM) that forms a barrier for T cells. Comparing …

The molecular mechanisms responsible for the sustained basal motility of T cells within
lymph nodes (LNs) remain elusive. To study T cell motility in a LN environment, we have …

Neisseria meningitidis is a commensal bacterium of the human nasopharynx. Occasionally,
this bacterium reaches the bloodstream and causes meningitis after crossing the blood–…

Clear cell renal cell carcinomas (RCC) frequently display inactivation of von Hippel-Lindau (VHL)
gene leading to increased level of hypoxia-inducible factors (HIF). In this study, we …

Aspergillus fumigatus is a ubiquitous mold that can cause severe infections in immunocompromised
patients, typically manifesting as invasive pulmonary aspergillosis (IPA). Adaptive …