Nuclear-architecture defects have been shown to correlate with the manifestation of a number
of human diseases as well as ageing 1 , 2 , 3 , 4 . It is therefore plausible that diseases …

Diseases affecting the kidney constitute a major health issue worldwide. Their incidence
and poor prognosis affirm the urgent need for the development of new therapeutic strategies. …

We previously identified multipotent stem cells within the lamina propria of the human olfactory
mucosa, located in the nasal cavity. We also demonstrated that this cell type differentiates …

Combination of stem cell-based approaches with gene-editing technologies represents an
attractive strategy for studying human disease and developing therapies. However, gene-…

Heart failure is a leading cause of mortality and morbidity in the developed world, partly
because mammals lack the ability to regenerate heart tissue. Whether this is due to evolutionary …

Background— Long noncoding RNAs (lncRNAs) have emerged as critical epigenetic
regulators with important functions in development and disease. Here, we sought to identify and …

Lineage conversion of one somatic cell type to another is an attractive approach for
generating specific human cell types. Lineage conversion can be direct, in the absence of …

Since the initial discovery that OCT4, SOX2, KLF4, and c-MYC overexpression sufficed for
the induction of pluripotency in somatic cells, methodologies replacing the original factors …

Stem cell–based therapy has been proposed as a potential means of treatment for a variety
of brain disorders. Because ethical and technical issues have so far limited the clinical …

Apolipoprotein E4 (APOEε4) is the major allelic risk factor for late-onset sporadic Alzheimer's
disease (sAD). Inflammation is increasingly considered as critical in sAD initiation and …