User profiles for Emmanuelle Godefroy
 | Emmanuelle GodefroyResearch Scientist CRCN/CR1 INSERM Verified email at inserm.fr Cited by 1179 |
A microbiota-modulated checkpoint directs immunosuppressive intestinal T cells into cancers
…, L Blanchard, JP Girard, A Jarry, N Gervois, E Godefroy… - Science, 2023 - science.org
Antibiotics (ABX) compromise the efficacy of programmed cell death protein 1 (PD-1)
blockade in cancer patients, but the mechanisms underlying their immunosuppressive effects …
blockade in cancer patients, but the mechanisms underlying their immunosuppressive effects …
Rapamycin-mediated enrichment of T cells with regulatory activity in stimulated CD4+ T cell cultures is not due to the selective expansion of naturally occurring …
…, V Tosello, NE Souleimanian, E Godefroy… - The Journal of …, 2006 - journals.aai.org
Rapamycin is an immunosuppressive drug currently used in different clinical settings.
Although the capacity of rapamycin to inhibit the mammalian target of rapamycin serine/threonine …
Although the capacity of rapamycin to inhibit the mammalian target of rapamycin serine/threonine …
Expression and release of HLA-E by melanoma cells and melanocytes: potential impact on the response of cytotoxic effector cells
…, B Charreau, A Moreau, E Godefroy… - The Journal of …, 2006 - journals.aai.org
HLA-E are nonclassical MHC molecules with poorly characterized tissue distribution and
functions. Because of their capacity to bind the inhibitory receptor, CD94/NKG2A, expressed by …
functions. Because of their capacity to bind the inhibitory receptor, CD94/NKG2A, expressed by …
[HTML][HTML] Faecalibacterium prausnitzii Skews Human DC to Prime IL10-Producing T Cells Through TLR2/6/JNK Signaling and IL-10, IL-27, CD39, and IDO-1 Induction
J Alameddine, E Godefroy, L Papargyris… - Frontiers in …, 2019 - frontiersin.org
The human colonic mucosa contains regulatory type 1-like (Tr1-like, ie, IL-10-secreting and
Foxp3-negative) T cells specific for the gut Clostridium Faecalibacterium prausnitzii (F. …
Foxp3-negative) T cells specific for the gut Clostridium Faecalibacterium prausnitzii (F. …
[HTML][HTML] Human CD4+ CD8α+ Tregs induced by Faecalibacterium prausnitzii protect against intestinal inflammation
S Touch, E Godefroy, N Rolhion, C Danne, C Oeuvray… - JCI insight, 2022 - ncbi.nlm.nih.gov
Abundance of Faecalibacterium prausnitzii, a dominant bacterium of the human microbiota
that exhibits antiinflammatory effects, is decreased in patients with inflammatory bowel …
that exhibits antiinflammatory effects, is decreased in patients with inflammatory bowel …
[HTML][HTML] TIGIT-positive circulating follicular helper T cells display robust B-cell help functions: potential role in sickle cell alloimmunization
E Godefroy, H Zhong, P Pham, D Friedman… - …, 2015 - ncbi.nlm.nih.gov
T follicular helper cells are the main CD4+ T cells specialized in supporting B-cell responses,
but their role in driving transfusion-associated alloimmunization is not fully characterized. …
but their role in driving transfusion-associated alloimmunization is not fully characterized. …
[PDF][PDF] Matrix metalloproteinase-2 conditions human dendritic cells to prime inflammatory TH2 cells via an IL-12-and OX40L-dependent pathway
E Godefroy, O Manches, B Dréno, T Hochman… - Cancer cell, 2011 - cell.com
Matrix metalloproteinase-2 (MMP-2) is a proteolytic enzyme degrading the extracellular
matrix and overexpressed by many tumors. Here, we documented the presence of MMP-2-…
matrix and overexpressed by many tumors. Here, we documented the presence of MMP-2-…
TLR4 Engagement during TLR3-Induced Proinflammatory Signaling in Dendritic Cells Promotes IL-10–Mediated Suppression of Antitumor Immunity
D Bogunovic, O Manches, E Godefroy, A Yewdall… - Cancer research, 2011 - AACR
Toll-like receptor (TLR) agonists are promising adjuvants for immune therapy of cancer, but
their potential efficacy as single or combinatorial agents has yet to be fully evaluated. Here, …
their potential efficacy as single or combinatorial agents has yet to be fully evaluated. Here, …
Expression of CCR6 and CXCR6 by gut-derived CD4+/CD8α+ T-regulatory cells, which are decreased in blood samples from patients with inflammatory bowel …
E Godefroy, J Alameddine, E Montassier, J Mathé… - Gastroenterology, 2018 - Elsevier
Background & Aims Faecalibacterium prausnitzii, a member of the Clostridium IV group of
the Firmicutes phylum that is abundant in the intestinal microbiota, has anti-inflammatory …
the Firmicutes phylum that is abundant in the intestinal microbiota, has anti-inflammatory …
[HTML][HTML] KBMA Listeria monocytogenes is an effective vector for DC-mediated induction of antitumor immunity
…, A Yewdall, KS Bahjat, E Godefroy… - The Journal of …, 2008 - Am Soc Clin Investig
Vaccine strategies that utilize human DCs to enhance antitumor immunity have yet to realize
their full potential. Approaches that optimally target a spectrum of antigens to DCs are …
their full potential. Approaches that optimally target a spectrum of antigens to DCs are …