Rheumatic diseases can be divided in two groups, autoinflammatory and autoimmune
disorders. The clinical presentation of both types of diseases overlap, but the pathological …

Psoriatic arthritis (PsA) is a heterogeneous, chronic inflammatory musculoskeletal disorder
that affects ~0.1% of the population. PsA may severely impact quality-of-life and constitutes a …

Objective Innate lymphoid cells (ILCs) are a recently discovered group of cells that are
essential to epithelial homeostasis and are implicated in psoriasis pathogenesis, yet they have …

Background: Early identification of patients at risk of psoriatic arthritis (PsA) is essential to
facilitate early diagnosis and improve clinical outcomes. Severe cutaneous psoriasis has been …

Objective To compare immune cell phenotype and function in psoriatic arthritis (PsA) versus
psoriasis in order to better understand the pathogenesis of PsA. Methods In‐depth …

CXCL4 regulates multiple facets of the immune response and is highly upregulated in various
Th17‐associated rheumatic diseases. However, whether CXCL4 plays a direct role in the …

Objective The role of innate lymphoid cells (ILCs) in the pathophysiology of rheumatic
diseases is emerging. Evidence from animal studies implicate type I IFN, produced by …

Dermal fibroblasts are strategically positioned underneath the basal epidermis layer to support
keratinocyte proliferation and extracellular matrix production. In inflammatory conditions, …

In psoriatic arthritis (PsA), predisposing class I HLA alleles, the presence of synovial clonally
proliferated CD8 + T cells and autoantibodies all point towards the loss of immune tolerance…

Background Psoriasis is an immune-mediated inflammatory skin disease. Psoriasis severity
evaluation is important for clinicians in the assessment of disease severity and subsequent …