Intellectual disability (ID) and autism spectrum disorder (ASD) are the most common
neurodevelopmental disorders and are characterized by substantial impairment in intellectual and …

Determining genes that orchestrate cell differentiation in development and disease remains
a fundamental goal of cell biology. This study establishes a genome-wide metric based on …

Pluripotent stem cells underpin a growing sector that leverages their differentiation potential
for research, industry, and clinical applications. This review evaluates the landscape of …

Methods for cell clustering and gene expression from single-cell RNA sequencing (scRNA-seq)
data are essential for biological interpretation of cell processes. Here, we present …

Histone deacetylases (HDACs) are a class of enzymes that control chromatin state and
influence cell fate. We evaluated the chromatin accessibility and transcriptome dynamics of zinc-…

Elucidating genetic determinants underpinning cell identity in development and disease
remains a fundamental goal of cell biology. Though technological advances now enable the …

Determining genes orchestrating cell identity and function in development and disease remains
a fundamental goal of cell biology. This study establishes a genome-wide metric based …

Life experiences influence our research and motivate us to ask scientific questions and shape
research goals. Here, Trends in Molecular Medicine authors share their journey in science…

How do cells deal with their heritage when finding their own path? Multipotent cells, which
have the potential to give rise to more than one cell type in development display multilineage …

We have developed ExAtlas, an on-line software tool for meta-analysis and visualization of
gene expression data. In contrast to existing software tools, ExAtlas compares multi-…