User profiles for Enda M Byrne

Enda Byrne

University of Queensland, Child Health Research Centre, Brisbane, Australia
Verified email at uq.edu.au
Cited by 21562

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

…, S Ripke, M Mattheisen, M Trzaskowski, EM Byrne… - Nature …, 2018 - nature.com
Major depressive disorder (MDD) is a common illness accompanied by considerable
morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide …

Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions

…, C Tian, DA Hinds, M Trzaskowski, EM Byrne… - Nature …, 2019 - nature.com
Major depression is a debilitating psychiatric illness that is typically associated with low
mood and anhedonia. Depression has a heritable component that has remained difficult to …

Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection

…, SA McCarroll, BT Baune, G Breen, EM Byrne… - Nature …, 2018 - nature.com
Schizophrenia is a debilitating psychiatric condition often associated with poor quality of life
and decreased life expectancy. Lack of progress in improving treatment outcomes has been …

Genome-wide association study identifies 30 loci associated with bipolar disorder

…, JMW Pavlides, M Trzaskowski, EM Byrne… - Nature …, 2019 - nature.com
Bipolar disorder is a highly heritable psychiatric disorder. We performed a genome-wide
association study (GWAS) including 20,352 cases and 31,358 controls of European descent, …

Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies

…, C He, KL Lunetta, JA Visser, EM Byrne… - Nature …, 2010 - nature.com
To identify loci for age at menarche, we performed a meta-analysis of 32 genome-wide
association studies in 87,802 women of European descent, with replication in up to 14,731 …

Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche

…, EM Byrne, JJ Hottenga, DL Koller, M Mangino… - Nature, 2014 - nature.com
Age at menarche is a marker of timing of puberty in females. It varies widely between
individuals, is a heritable trait and is associated with risks for obesity, type 2 diabetes, …

Meta-analysis of genome-wide association studies of anxiety disorders

T Otowa, K Hek, M Lee, EM Byrne, SS Mirza… - Molecular …, 2016 - nature.com
Anxiety disorders (ADs), namely generalized AD, panic disorder and phobias, are common,
etiologically complex conditions with a partially genetic basis. Despite differing on diagnostic …

[HTML][HTML] Genome-wide association analyses of chronotype in 697,828 individuals provides insights into circadian rhythms

…, JW Harrison, A Dawes, EM Byrne… - Nature …, 2019 - nature.com
Being a morning person is a behavioural indicator of a person’s underlying circadian rhythm.
Using genome-wide data from 697,828 UK Biobank and 23andMe participants we …

Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression

…, TM Air, R Araya, L Bowes, R Burns, EM Byrne… - Molecular …, 2018 - nature.com
The hypothesis that the S allele of the 5-HTTLPR serotonin transporter promoter region is
associated with increased risk of depression, but only in individuals exposed to stressful …

Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways

…, M Mangino, P Sulem, M Barbalic, L Broer, EM Byrne… - Nature …, 2012 - nature.com
To newly identify loci for age at natural menopause, we carried out a meta-analysis of 22
genome-wide association studies (GWAS) in 38,968 women of European descent, with …