Identification of drug-like small molecules that alter protein–protein interactions might be a
key step in drug discovery. However, it is very challenging to find such molecules that target …

Recent advances in 3D culture systems have led to the generation of brain organoids that
resemble different human brain regions; however, a 3D organoid model of the midbrain …

The PRISM web server enables fast and accurate prediction of protein–protein interactions (PPIs).
The prediction algorithm is knowledge-based. It combines structural similarity and …

Most human protein-coding genes are regulated by multiple, distinct promoters, suggesting
that the choice of promoter is as important as its level of transcriptional activity. However, …

B lymphocytes are important players in immune responses to cancer. However, their composition
and function in head and neck squamous cell carcinoma (HNSCC) has not been well …

Hot spots are energetically important residues at protein interfaces and they are not randomly
distributed across the interface but rather clustered. These clustered hot spots form hot …

The fact that Parkinson's disease (PD) can arise from numerous genetic mutations suggests
a unifying molecular pathology underlying the various genetic backgrounds. To address this …

Improvements in experimental techniques increasingly provide structural data relating to
protein-protein interactions. Classification of structural details of protein-protein interactions can …

The RNA-binding protein SRSF3 (also known as SRp20) has critical roles in the regulation
of pre-mRNA splicing. Zygotic knockout of Srsf3 results in embryo arrest at the blastocyst …

Tumor-infiltrating lymphocytes (TILs) are correlated to prognosis of several kinds of cancer.
Most studies focused on T cells, while the role of tumor-associated B cells (TABs) has only …