User profiles for Ennio Prosperi
 | ennio prosperiIstituto di Genetica Molecolare del CNR Verified email at igm.cnr.it Cited by 5490 |
[HTML][HTML] Specific structural determinants are responsible for the antioxidant activity and the cell cycle effects of resveratrol
Resveratrol (3,4′,5-trihydroxy-trans-stilbene) is a natural phytoalexin found in grapes and
wine, which shows antioxidant and antiproliferative activities. In this study we have …
wine, which shows antioxidant and antiproliferative activities. In this study we have …
Multiple roles of the cell cycle inhibitor p21CDKN1A in the DNA damage response
Among cell cycle regulatory proteins that are activated following DNA damage, the cyclin-dependent
kinase inhibitor p21 CDKN1A plays essential roles in the DNA damage response, …
kinase inhibitor p21 CDKN1A plays essential roles in the DNA damage response, …
Arylthioindole inhibitors of tubulin polymerization. 3. Biological evaluation, structure− activity relationships and molecular modeling studies
The new arylthioindole (ATI) derivatives 10, 14−18, and 21−24, which bear a halogen atom
or a small size ether group at position 5 of the indole moiety, were compared with the …
or a small size ether group at position 5 of the indole moiety, were compared with the …
Biology of the cell cycle inhibitor p21CDKN1A: molecular mechanisms and relevance in chemical toxicology
The cell cycle inhibitor p21 CDKN1A is a protein playing multiple roles not only in the DNA
damage response, but also in many cellular processes during unperturbed cell growth. The …
damage response, but also in many cellular processes during unperturbed cell growth. The …
Targeting proliferating cell nuclear antigen (PCNA) as an effective strategy to inhibit tumor cell proliferation
M Cardano, C Tribioli, E Prosperi - Current cancer drug targets, 2020 - ingentaconnect.com
Targeting highly proliferating cells is an important issue for many types of aggressive tumors.
Proliferating Cell Nuclear Antigen (PCNA) is an essential protein that participates in a …
Proliferating Cell Nuclear Antigen (PCNA) is an essential protein that participates in a …
The cyclin-dependent kinase inhibitors olomoucine and roscovitine arrest human fibroblasts in G1 phase by specific inhibition of CDK2 kinase activity
The specificity and the temporal location of cell cycle arrest induced by the cyclin-dependent
kinase (CDK) inhibitors olomoucine and roscovitine were investigated in normal human …
kinase (CDK) inhibitors olomoucine and roscovitine were investigated in normal human …
Multiple roles of the proliferating cell nuclear antigen: DNA replication, repair and cell cycle control
E Prosperi - Progress in cell cycle research, 1997 - Springer
The proliferating cell nuclear antigen (PCNA), the auxiliary protein of DNA polymerases δ
and ε, is involved in DNA replication and repair. This protein forms a homotrimeric structure …
and ε, is involved in DNA replication and repair. This protein forms a homotrimeric structure …
CBP and p300 acetylate PCNA to link its degradation with nucleotide excision repair synthesis
The proliferating cell nuclear antigen (PCNA) protein serves as a molecular platform
recruiting and coordinating the activity of factors involved in multiple deoxyribonucleic acid (DNA) …
recruiting and coordinating the activity of factors involved in multiple deoxyribonucleic acid (DNA) …
Replication fork stalling in WRN-deficient cells is overcome by prompt activation of a MUS81-dependent pathway
A Franchitto, LM Pirzio, E Prosperi, O Sapora… - The Journal of cell …, 2008 - rupress.org
Failure to stabilize and properly process stalled replication forks results in chromosome
instability, which is a hallmark of cancer cells and several human genetic conditions that are …
instability, which is a hallmark of cancer cells and several human genetic conditions that are …
CREBBP and p300 lysine acetyl transferases in the DNA damage response
I Dutto, C Scalera, E Prosperi - Cellular and Molecular Life Sciences, 2018 - Springer
The CREB-binding protein (CREBBP, or in short CBP) and p300 are lysine (K) acetyl
transferases (KAT) belonging to the KAT3 family of proteins known to modify histones, as well as …
transferases (KAT) belonging to the KAT3 family of proteins known to modify histones, as well as …