Heterogeneous pools of adult neural stem cells (NSCs) contribute to brain maintenance
and regeneration after injury. The balance of NSC activation and quiescence, as well as the …

The function of somatic stem cells declines with age. Understanding the molecular underpinnings
of this decline is key to counteract age-related disease. Here, we report a dramatic …

INTRODUCTION The capacity of a tissue to regenerate itself rests on the potential of its
resident cells to replace cells lost to injury. Some tissues, such as skin or intestine, do this …

Mature oligodendrocytes (MOLs) show transcriptional heterogeneity, the functional consequences
of which are unclear. MOL heterogeneity might correlate with the local environment or …

Parenchymal astrocytes have emerged as a potential reservoir for new neurons in non-neurogenic
brain regions. It is currently unclear how astrocyte neurogenesis is controlled …

Whether post-transcriptional regulation of gene expression controls differentiation of stem
cells for tissue renewal remains unknown. Quiescent stem cells exhibit a low level of protein …

Current methods for epigenomic profiling are limited in their ability to obtain genome-wide
information with spatial resolution. We introduce spatial ATAC, a method that integrates …

Whether new neurons are added in the postnatal cerebral cortex is still debated. Here, we
report that the meninges of perinatal mice contain a population of neurogenic progenitors …

Regulation of adult neural stem cell ( NSC ) number is critical for lifelong neurogenesis. Here,
we identified a post‐transcriptional control mechanism, centered around the micro RNA …

The role of CD95 (Fas/Apo1) in cancer has been a matter of debate for over 30 years. First
discovered as an apoptosis-inducing molecule, CD95 soon emerged as a potential …