Empiric probiotics are commonly consumed by healthy individuals as means of life quality
improvement and disease prevention. However, evidence of probiotic gut mucosal …

Probiotics are widely prescribed for prevention of antibiotics-associated dysbiosis and
related adverse effects. However, probiotic impact on post-antibiotic reconstitution of the gut …

The TP53 gene is frequently mutated in human cancer. Research has focused predominantly
on six major "hotspot" codons, which account for only ∼30% of cancer-associated p53 …

Embryonic stem cells (ESCs) maintain high genomic plasticity, which is essential for their
capacity to enter diverse differentiation pathways. Posttranscriptional modifications of …

The earliest events during human tumour initiation, although poorly characterized, may hold
clues to malignancy detection and prevention 1 . Here we model occult preneoplasia by …

In this multicenter, open-label, randomized phase II investigator-sponsored neoadjuvant
trial with funding provided by Sanofi and GlaxoSmithKline (TRIO-US B07, Clinical Trials …

The microRNA miR-504 targets TP53 mRNA encoding the p53 tumor suppressor. miR-504
resides within the fibroblast growth factor 13 (FGF13) gene, which is overexpressed in …

The addition of HER2-targeted agents to neoadjuvant chemotherapy has dramatically improved
pathological complete response (pCR) rates in early-stage, HER2-positive breast cancer…

Hoher Widerstand: Mithilfe einer effizienten Methode zum Aufbau N‐methylierter
Isopeptidbindungen wurden stabile ubiquitinierte Peptide und Proteine hergestellt, die …

The earliest events during human tumor initiation, while poorly characterized, may hold
clues to malignancy detection and prevention 1 . Here we model occult pre-neoplasia by bi-…