mRNA modifications play important roles in regulating gene expression. One of the most
abundant mRNA modifications is N6,2-O-dimethyladenosine (m6Am). Here, we demonstrate …

The emerging "epitranscriptomics" field is providing insights into the biological and pathological
roles of different RNA modifications. The RNA methyltransferase METTL1 catalyzes N7-…

Dear Editor, An ideal cancer therapy drug should kill cancer cells while displaying limited
toxicities toward normal cells 1. Therefore, genes essential in cancer but not normal cells are …

In mammalian cells, DNA methylation on the fifth position of cytosine (5mC) plays an important
role as an epigenetic mark. However, DNA methylation was considered to be absent in C. …

Since the early days of foundational studies of nucleic acids, many chemical moieties have
been discovered to decorate RNA and DNA in diverse organisms. In mammalian cells, one of …

N6-methyladenosine (m 6 A), the most abundant modification of mRNA, is essential for
normal development and dysregulation promotes cancer. m 6 A is highly enriched in the 3’ …

Cellular RNAs are subject to a myriad of different chemical modifications that play important
roles in controlling RNA expression and function. Dysregulation of certain RNA modifications…

The fates of RNA species in a cell are controlled by ribonucleases, which degrade them by
exploiting the universal structural 2′-OH group. This phenomenon plays a key role in …

Dear Editor, One of the most abundant RNA modifications is N6-methyladenosine (m6A),
which is present in RNA from all forms of life, including viruses. This modification has been …

In Saccharomyces cerevisiae, transcriptional silencing occurs at the cryptic mating-type loci (HML
and HMR), telomeres, and ribosomal DNA (rDNA; RDN1). Silencing in the rDNA is …