While amino acid restriction remains an attractive strategy for cancer therapy, metabolic
adaptations limit its effectiveness. Here we demonstrate a role of translational reprogramming in …

Weekly gemcitabine therapy is the major treatment offered for patients with pancreatic
adenocarcinoma cancer; however, relative resistance of tumor cells to chemotherapy, rapid …

Low-dose metronomic (LDM) chemotherapy represents an emerging concept in the treatment
of cancer. Directed against tumor cells and other types of cells, such as endothelial and …

Oral squamous cell carcinoma (SCC) is most induced by exposure of the oral epithelial cells
to tobacco products such as cigarette smoke. This exposure always occurs in the presence …

Capecitabine-based neoadjuvant chemoradiation therapy (nCRT) is currently the mainstay
of treatment for locally advanced rectal cancer (LARC), prior to surgical tumor removal. While …

Background Surveillance of high‐risk individuals for pancreatic ductal adenocarcinoma (PDAC)
is recommended. This study aimed to determine the prevalence and outcomes of PDAC …

Although the free radical theory of aging is widely accepted among scientists, the possibility
of using antioxidants to delay the aging processes seems to encounter considerable …

Lynch syndrome (LS) is a hereditary cancer syndrome caused by autosomal dominant
mutations, with high probability of early onset for several cancers, mainly colorectal cancer (CRC)…

There is an urgent need to define mechanisms underlying pancreatic adenocarcinoma (PDA)
development. Our studies of ubiquitin ligases that may underlie PDA development led us …

MicroRNAs (miRs) seem to mediate renal fibrosis in several renal diseases, with some
miRs having profibrotic effects and others having opposing effects. Although differential …