We describe Hi-C, a method that probes the three-dimensional architecture of whole genomes
by coupling proximity-based ligation with massively parallel sequencing. We constructed …

We use in situ Hi-C to probe the 3D architecture of genomes, constructing haploid and diploid
maps of nine cell types. The densest, in human lymphoblastoid cells, contains 4.9 billion …

We constructed a corpus of digitized texts containing about 4% of all books ever printed.
Analysis of this corpus enables us to investigate cultural trends quantitatively. We survey the …

Hi-C experiments explore the 3D structure of the genome, generating terabases of data to
create high-resolution contact maps. Here, we introduce Juicer, an open-source tool for …

The Zika outbreak, spread by the Aedes aegypti mosquito, highlights the need to create high-quality
assemblies of large genomes in a rapid and cost-effective way. Here we combine Hi-…

We recently used in situ Hi-C to create kilobase-resolution 3D maps of mammalian genomes.
Here, we combine these maps with new Hi-C, microscopy, and genome-editing …

The human genome folds to create thousands of intervals, called "contact domains," that
exhibit enhanced contact frequency within themselves. "Loop domains" form because of …

Hi-C experiments study how genomes fold in 3D, generating contact maps containing
features as small as 20 bp and as large as 200 Mb. Here we introduce Juicebox, a tool for …

The three-dimensional folding of chromosomes compartmentalizes the genome and and
can bring distant functional elements, such as promoters and enhancers, into close spatial …

November 2020 marked 2 y since the launch of the Earth BioGenome Project (EBP), which
aims to sequence all known eukaryotic species in a 10-y timeframe. Since then, significant …