Identifying reliable biomarkers of aging is a major goal in geroscience. While the first
generation of epigenetic biomarkers of aging were developed using chronological age as a …

It was unknown whether plasma protein levels can be estimated based on DNA methylation
(DNAm) levels, and if so, how the resulting surrogates can be consolidated into a powerful …

Age is the dominant risk factor for most chronic human diseases, but the mechanisms
through which ageing confers this risk are largely unknown 1 . The age-related acquisition of …

… Dr Whitsel reported receiving grants from the National Heart, Lung, and Blood Institute, the
National Institute of Environmental Health Sciences, the National Institute of Child Health and …

Behavioral and lifestyle factors have been shown to relate to a number of health-related
outcomes, yet there is a need for studies that examine their relationship to molecular aging rates…

Cardiac autonomic activity, as assessed by heart rate variability, has been found to be
associated with postmyocardial infarction mortality, sudden death, and all-cause mortality. …

DNA methylation (DNAm)-based biomarkers of aging have been developed for many tissues
and organs. However, these biomarkers have sub-optimal accuracy in fibroblasts and other …

The National Longitudinal Study of Adolescent Health (Add Health) was developed in the
1990s in response to a mandate from the United States Congress to fund a study of adolescent …

PURPOSE: It is unclear whether intramuscular administration of testosterone esters to
hypogonadal men is associated with changes in plasma lipids. We therefore analyzed 19 studies …

Statins effectively lower LDL cholesterol levels in large studies and the observed interindividual
response variability may be partially explained by genetic variation. Here we perform a …