Micro RNAs are a large family of noncoding RNAs of 21–22 nucleotides whose functions are
generally unknown. Here a large subset of Drosophila micro RNAs is shown to be perfectly …

To gain insight into how genomic information is translated into cellular and developmental
programs, the Drosophila model organism Encyclopedia of DNA Elements (modENCODE) …

We systematically generated large-scale data sets to improve genome annotation for the
nematode Caenorhabditis elegans, a key model organism. These data sets include …

Notch is a transmembrane receptor that mediates local cell-cell communication and coordinates
a signaling cascade present in all animal species studied to date. Notch signaling is …

The canonical microRNA (miRNA) pathway converts primary hairpin precursor transcripts
into ∼22 nucleotide regulatory RNAs via consecutive cleavages by two RNase III enzymes, …

Mirtrons are alternative precursors for microRNA biogenesis that were recently described in
invertebrates. These short hairpin introns use splicing to bypass Drosha cleavage, which is …

… On the basis of this experience, the NHGRI launched two complementary programmes in
2007: an expansion of the human ENCODE project to the whole genome (http://www.genome.gov/ENCODE) …

Background MicroRNAs (miRNAs) are a large family of 21-22 nucleotide non-coding RNAs
with presumed post-transcriptional regulatory activity. Most miRNAs were identified by direct …

Regulation of gene activity by microRNAs is critical to myriad aspects of eukaryotic
development and physiology. Amidst an extensive regulatory web that is predicted to involve …

Circularization was recently recognized to broadly expand transcriptome complexity. Here,
we exploit massive Drosophila total RNA-sequencing data, >5 billion paired-end reads from >…