A host of observations demonstrating the relationship between nuclear architecture and
processes such as gene expression have led to a number of new technologies for interrogating …

Fluorescence in situ hybridization (FISH) is a powerful single-cell technique for studying
nuclear structure and organization. Here we report two advances in FISH-based imaging. We …

Widespread changes to DNA methylation and chromatin are well documented in cancer,
but the fate of higher-order chromosomal structure remains obscure. Here we integrated …

The pairing of homologous chromosomes is a fundamental feature of the meiotic cell. In
addition, a number of species exhibit homolog pairing in nonmeiotic, somatic cells as well, with …

Higher-order chromatin structure regulates gene expression, and mutations in proteins
mediating genome folding underlie developmental disorders known as cohesinopathies. …

Ataxia telangiectasia–mutated (ATM) and ataxia telangiectasia–related (ATR) kinases are
conserved regulators of cellular responses to double strand breaks (DSBs). During meiosis, …

Background Association of chromatin with lamin proteins at the nuclear periphery has emerged
as a potential mechanism to coordinate cell type-specific gene expression and maintain …

Topologically Associating Domains (TADs) separate vertebrate genomes into insulated
regulatory neighborhoods that focus genome-associated processes. TADs are formed by …

The human genome can be segmented into topologically associating domains (TADs),
which have been proposed to spatially sequester genes and regulatory elements through …

Nuclear speckles are prominent nuclear bodies that contain proteins and RNA involved in
gene expression. Although links between nuclear speckles and gene activation are emerging, …