Impaired facial emotion perception in schizophrenia: a meta-analysis

RCK Chan, H Li, EFC Cheung, QY Gong - Psychiatry research, 2010 - Elsevier
Research into facial emotion perception in schizophrenia has burgeoned over the past several
decades. The evidence is mixed regarding whether patients with schizophrenia have a …

Revisiting the therapeutic effect of rTMS on negative symptoms in schizophrenia: a meta-analysis

C Shi, X Yu, EFC Cheung, DHK Shum, RCK Chan - Psychiatry research, 2014 - Elsevier
This study sought to determine the moderators in the treatment effect of repetitive transcranial
magnetic stimulation (rTMS) on negative symptoms in schizophrenia. We performed a meta…

Mapping genomic loci implicates genes and synaptic biology in schizophrenia

…, RCK Chan, B Chaumette, W Cheng, EFC Cheung… - Nature, 2022 - nature.com
Schizophrenia has a heritability of 60–80% 1 , much of which is attributable to common risk
alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with …

[PDF][PDF] Modeling linkage disequilibrium increases accuracy of polygenic risk scores

…, RYL Chen, EYH Chen, W Cheng, EFC Cheung… - The american journal of …, 2015 - cell.com
Polygenic risk scores have shown great promise in predicting complex disease risk and will
become more accurate as training sample sizes increase. The standard approach for …

Multisensory temporal binding window in autism spectrum disorders and schizophrenia spectrum disorders: A systematic review and meta-analysis

H Zhou, X Cai, M Weigl, P Bang, EFC Cheung… - Neuroscience & …, 2018 - Elsevier
Multisensory temporal integration could be compromised in both autism spectrum disorders
(ASD) and schizophrenia spectrum disorders (SSD) and may play an important role in …

[PDF][PDF] Partitioning heritability of regulatory and cell-type-specific variants across 11 common diseases

…, RYL Chen, EYH Chen, W Cheng, EFC Cheung… - The American Journal of …, 2014 - cell.com
Regulatory and coding variants are known to be enriched with associations identified by
genome-wide association studies (GWASs) of complex disease, but their contributions to trait …

[PDF][PDF] Genomic dissection of bipolar disorder and schizophrenia, including 28 subphenotypes

…, EYH Chen, RYL Chen, W Cheng, EFC Cheung… - Cell, 2018 - cell.com
Schizophrenia and bipolar disorder are two distinct diagnoses that share symptomology.
Understanding the genetic factors contributing to the shared and disorder-specific symptoms …

Motivational deficits in effort-based decision making in individuals with subsyndromal depression, first-episode and remitted depression patients

XH Yang, J Huang, C Zhu, Y Wang, EFC Cheung… - Psychiatry …, 2014 - Elsevier
Anhedonia is a hallmark symptom of major depressive disorder (MDD). Preliminary findings
suggest that anhedonia is characterized by reduced reward anticipation and motivation of …

Meta‐analysis of neuropsychological measures of executive functioning in children and adolescents with high‐functioning autism spectrum disorder

…, Q Chan, KM Cheng, SM Lam, EFC Cheung - Autism …, 2017 - Wiley Online Library
Existing literature on the profile of executive dysfunction in autism spectrum disorder showed
inconsistent results. Age, comorbid attention‐deficit/hyperactivity disorder (ADHD) and …

A comparison of ten polygenic score methods for psychiatric disorders applied across multiple cohorts

…, RYL Chen, EYH Chen, W Cheng, EFC Cheung… - Biological …, 2021 - Elsevier
Background Polygenic scores (PGSs), which assess the genetic risk of individuals for a disease,
are calculated as a weighted count of risk alleles identified in genome-wide association …