Acid-sensing ion channels (ASICs) are voltage-independent, proton-activated receptors that
belong to the epithelial sodium channel/degenerin family of ion channels and are …

Antidepressants targeting Na + /Cl − -coupled neurotransmitter uptake define a key
therapeutic strategy to treat clinical depression and neuropathic pain. However, identifying the …

Glutamate-gated AMPA receptors mediate the fast component of excitatory signal transduction
at chemical synapses throughout all regions of the mammalian brain. AMPA receptors are …

Na + /Cl - -dependent transporters terminate synaptic transmission by using electrochemical
gradients to drive the uptake of neurotransmitters, including the biogenic amines, from the …

Crystal structures of the GluR2 ligand binding core (S1S2) have been determined in the apo
state and in the presence of the antagonist DNQX, the partial agonist kainate, and the full …

The transport of ions across the membranes of cells and organelles is a prerequisite for
many of life's processes. Transport often involves very precise selectivity for specific ions. …

The serotonin transporter (SERT) terminates serotonergic signalling through the sodium-
and chloride-dependent reuptake of neurotransmitter into presynaptic neurons. SERT is a …

α‐Hemolysin from Staphylococcus aureus assembles from a water‐soluble, monomeric
species to a membrane‐bound heptamer on the surface of target cells, creating water‐filled …

Ionotropic glutamate receptors mediate most excitatory neurotransmission in the central
nervous system and function by opening a transmembrane ion channel upon binding of …

Fast inhibitory neurotransmission is essential for nervous system function and is mediated by
binding of inhibitory neurotransmitters to receptors of the Cys-loop family embedded in the …