User profiles for Eric J. Aird
Eric AirdPostdoctoral Researcher, ETH Zurich Verified email at biol.ethz.ch Cited by 354 |
[HTML][HTML] Increasing Cas9-mediated homology-directed repair efficiency through covalent tethering of DNA repair template
The CRISPR-Cas9 system is a powerful genome-editing tool in which a guide RNA targets
Cas9 to a site in the genome, where the Cas9 nuclease then induces a double-stranded …
Cas9 to a site in the genome, where the Cas9 nuclease then induces a double-stranded …
[HTML][HTML] Recursive Editing improves homology-directed repair through retargeting of undesired outcomes
CRISPR-Cas induced homology-directed repair (HDR) enables the installation of a broad
range of precise genomic modifications from an exogenous donor template. However, …
range of precise genomic modifications from an exogenous donor template. However, …
Molecular underpinnings of ssDNA specificity by Rep HUH-endonucleases and implications for HUH-tag multiplexing and engineering
Replication initiator proteins (Reps) from the HUH-endonuclease superfamily process
specific single-stranded DNA (ssDNA) sequences to initiate rolling circle/hairpin replication in …
specific single-stranded DNA (ssDNA) sequences to initiate rolling circle/hairpin replication in …
Enhanced molecular tension sensor based on bioluminescence resonance energy transfer (BRET)
Molecular tension sensors measure piconewton forces experienced by individual proteins
in the context of the cellular microenvironment. Current genetically encoded tension sensors …
in the context of the cellular microenvironment. Current genetically encoded tension sensors …
Programmable Assembly of Adeno-Associated Virus–Antibody Composites for Receptor-Mediated Gene Delivery
Adeno-associated virus (AAV) has emerged as a viral gene delivery vector that is safe in
humans, able to infect both dividing and arrested cells and drive long-term expression (>6 …
humans, able to infect both dividing and arrested cells and drive long-term expression (>6 …
A toolkit for studying cell surface shedding of diverse transmembrane receptors
10.7554/eLife.46983.001 Proteolysis of transmembrane receptors is a critical cellular
communication mechanism dysregulated in disease, yet decoding proteolytic regulation …
communication mechanism dysregulated in disease, yet decoding proteolytic regulation …
Split Staphylococcus aureus prime editor for AAV delivery
Prime editing brings immense promise to correct a large number of human pathogenic
mutations and enact diverse edit types without introducing widespread undesired editing events. …
mutations and enact diverse edit types without introducing widespread undesired editing events. …
[PDF][PDF] SNAPS: a toolkit for studying cell surface shedding of diverse transmembrane receptors
Proteolysis of transmembrane receptors is a critical cellular communication mechanism
dysregulated in many diseases, yet decoding proteolytic regulation mechanisms of the estimated …
dysregulated in many diseases, yet decoding proteolytic regulation mechanisms of the estimated …
Novel precise genome editing technologies
EJ Aird - 2020 - search.proquest.com
Genome engineering, the ability to manipulate and modify genomes, has become a standard
tool in life sciences and beyond. Programmable nucleases such as CRISPR-Cas9 have …
tool in life sciences and beyond. Programmable nucleases such as CRISPR-Cas9 have …
[PDF][PDF] Development of a BRET-Based Molecular Tension Sensor to Study Altered Tensions in Disease Pathogenesis
EJ Aird, KJ Tompkins, WR Gordon - Biophysical Journal, 2018 - cell.com
Alteration of mechanical forces is an emerging factor in diseases like cancer. Changes in
macroscopic stiffness in disease are accompanied by a wealth of changes in a cell's tensional …
macroscopic stiffness in disease are accompanied by a wealth of changes in a cell's tensional …