User profiles for Eric J. Aird

Eric Aird

Postdoctoral Researcher, ETH Zurich
Verified email at biol.ethz.ch
Cited by 354

[HTML][HTML] Increasing Cas9-mediated homology-directed repair efficiency through covalent tethering of DNA repair template

EJ Aird, KN Lovendahl, A St. Martin, RS Harris… - Communications …, 2018 - nature.com
The CRISPR-Cas9 system is a powerful genome-editing tool in which a guide RNA targets
Cas9 to a site in the genome, where the Cas9 nuclease then induces a double-stranded …

[HTML][HTML] Recursive Editing improves homology-directed repair through retargeting of undesired outcomes

L Möller, EJ Aird, MS Schröder, L Kobel… - Nature …, 2022 - nature.com
CRISPR-Cas induced homology-directed repair (HDR) enables the installation of a broad
range of precise genomic modifications from an exogenous donor template. However, …

Molecular underpinnings of ssDNA specificity by Rep HUH-endonucleases and implications for HUH-tag multiplexing and engineering

KJ Tompkins, M Houtti, LA Litzau, EJ Aird… - Nucleic acids …, 2021 - academic.oup.com
Replication initiator proteins (Reps) from the HUH-endonuclease superfamily process
specific single-stranded DNA (ssDNA) sequences to initiate rolling circle/hairpin replication in …

Enhanced molecular tension sensor based on bioluminescence resonance energy transfer (BRET)

EJ Aird, KJ Tompkins, MP Ramirez, WR Gordon - ACS sensors, 2019 - ACS Publications
Molecular tension sensors measure piconewton forces experienced by individual proteins
in the context of the cellular microenvironment. Current genetically encoded tension sensors …

Programmable Assembly of Adeno-Associated Virus–Antibody Composites for Receptor-Mediated Gene Delivery

AC Zdechlik, Y He, EJ Aird, WR Gordon… - Bioconjugate …, 2019 - ACS Publications
Adeno-associated virus (AAV) has emerged as a viral gene delivery vector that is safe in
humans, able to infect both dividing and arrested cells and drive long-term expression (>6 …

A toolkit for studying cell surface shedding of diverse transmembrane receptors

AN Hayward, EJ Aird, WR Gordon - Elife, 2019 - elifesciences.org
10.7554/eLife.46983.001 Proteolysis of transmembrane receptors is a critical cellular
communication mechanism dysregulated in disease, yet decoding proteolytic regulation …

Split Staphylococcus aureus prime editor for AAV delivery

EJ Aird, AC Zdechlik, BL Ruis, CB Rogers, AL Lemmex… - bioRxiv, 2021 - biorxiv.org
Prime editing brings immense promise to correct a large number of human pathogenic
mutations and enact diverse edit types without introducing widespread undesired editing events. …

[PDF][PDF] SNAPS: a toolkit for studying cell surface shedding of diverse transmembrane receptors

AN Hayward, EJ Aird, WR Gordon - bioRxiv, 2018 - academia.edu
Proteolysis of transmembrane receptors is a critical cellular communication mechanism
dysregulated in many diseases, yet decoding proteolytic regulation mechanisms of the estimated …

Novel precise genome editing technologies

EJ Aird - 2020 - search.proquest.com
Genome engineering, the ability to manipulate and modify genomes, has become a standard
tool in life sciences and beyond. Programmable nucleases such as CRISPR-Cas9 have …

[PDF][PDF] Development of a BRET-Based Molecular Tension Sensor to Study Altered Tensions in Disease Pathogenesis

EJ Aird, KJ Tompkins, WR Gordon - Biophysical Journal, 2018 - cell.com
Alteration of mechanical forces is an emerging factor in diseases like cancer. Changes in
macroscopic stiffness in disease are accompanied by a wealth of changes in a cell's tensional …