For more than three-quarters of a century it has been assumed 1 that basal metabolic rate
increases as body mass raised to some power p. However, there is no broad consensus …

With the recent explosion in the size of libraries available for screening, virtual screening is
positioned to assume a more prominent role in early drug discovery’s search for active …

The capacity of proteins to interact specifically with one another underlies our conceptual
understanding of how living systems function. Systems-level study of specificity in protein–…

High-dimensional data are becoming increasingly common in nearly all areas of science.
Developing approaches to analyze these data and understand their meaning is a pressing …

Metabolic rate, heart rate, lifespan, and many other physiological properties vary with body
mass in systematic and interrelated ways. Present empirical data suggest that these scaling …

Signal transduction networks allow eukaryotic cells to make decisions based on information
about intracellular state and the environment. Biochemical noise significantly diminishes the …

Two-component Signaling (TCS) serves as the dominant signaling modality in bacteria. A
typical pathway includes a sensor Histidine Kinase (HK) that phosphorylates a Response …

All living things have evolved to sense changes in their environment in order to respond in
adaptive ways. At the cellular level, these sensing systems generally involve receptor …

It has recently been demonstrated that many biological networks exhibit a “scale-free” topology,
for which the probability of observing a node with a certain number of edges (k) follows a …

Computational methodologies are increasingly addressing modeling of the whole cell at the
molecular level. Proteins and their interactions are the key component of cellular processes. …