A comparison of BTA stat, hemoglobin dipstick, telomerase and Vysis UroVysion assays for the detection of urothelial carcinoma in urine
…, RJ Karnes, RG Meyer, EL Powell… - The Journal of …, 2002 - auajournals.org
Purpose : We determine the sensitivity and specificity of various assays for the detection of
urothelial carcinoma. Materials and Methods : A total of 280 voided urine specimens from 265 …
urothelial carcinoma. Materials and Methods : A total of 280 voided urine specimens from 265 …
First-in-human study of PF-06647020 (Cofetuzumab Pelidotin), an antibody–drug conjugate targeting protein tyrosine kinase 7, in advanced solid tumors
…, N Lakhani, AR Moreau, D Xuan, R Li, EL Powell… - Clinical Cancer …, 2021 - AACR
Purpose: We investigated safety, tolerability, pharmacokinetics, and antitumor activity of the
protein tyrosine kinase 7 (PTK7)-targeted, auristatin-based antibody–drug conjugate (ADC) …
protein tyrosine kinase 7 (PTK7)-targeted, auristatin-based antibody–drug conjugate (ADC) …
[HTML][HTML] Pixelwise H-score: a novel digital image analysis-based metric to quantify membrane biomarker expression from immunohistochemistry images
…, S Pirie-Shepherd, X Xia, EL Powell - PLoS …, 2021 - journals.plos.org
Immunohistochemistry (IHC) assays play a central role in evaluating biomarker expression
in tissue sections for diagnostic and research applications. Manual scoring of IHC images, …
in tissue sections for diagnostic and research applications. Manual scoring of IHC images, …
Concordant loss of MTAP and p16/CDKN2A expression in gastroesophageal carcinogenesis: evidence of homozygous deletion in esophageal noninvasive precursor …
EL Powell, LM Leoni, MI Canto… - The American journal …, 2005 - journals.lww.com
The gene that encodes methylthioadenosine phosphorylase (MTAP), an enzyme involved
in adenine and methionine salvage pathways, is located on chromosome 9p21 telomeric to …
in adenine and methionine salvage pathways, is located on chromosome 9p21 telomeric to …
PF-06647020 (PF-7020), an antibody-drug conjugate (ADC) targeting protein tyrosine kinase 7 (PTK7), in patients (pts) with advanced solid tumors: Results of a …
…, NJ Lakhani, B Gibson, D Xuan, T Joh, EL Powell… - 2018 - ascopubs.org
5565 Background: PF-7020 is an ADC comprising of a humanized monoclonal antibody
against PTK7, a cleavable valine-citrulline linker and auristatin payload that is being …
against PTK7, a cleavable valine-citrulline linker and auristatin payload that is being …
[HTML][HTML] Quantitative performance assessment of Ultivue multiplex panels in formalin-fixed, paraffin-embedded human and murine tumor specimens
…, JK Aguilar, T Coskran, EL Powell… - Scientific Reports, 2024 - nature.com
We present a rigorous validation strategy to evaluate the performance of Ultivue multiplex
immunofluorescence panels. We have quantified the accuracy and precision of four different …
immunofluorescence panels. We have quantified the accuracy and precision of four different …
[HTML][HTML] A refined compilation of implementation strategies: results from the Expert Recommendations for Implementing Change (ERIC) project
… The utility of this compilation will be extended in subsequent stages of the ERIC study.
We conclude by echoing Powell et al.’s [10] caution that this compilation, while substantially …
We conclude by echoing Powell et al.’s [10] caution that this compilation, while substantially …
Identification of antigens of pathogenic free-living amoebae by protein immunoblotting with rabbit immune and human sera.
EL Powell, AL Newsome, SD Allen… - Clinical and Diagnostic …, 1994 - ncbi.nlm.nih.gov
Prominent antigens of pathogenic and nonpathogenic free-living amoebae were identified
by using polyclonal rabbit immune sera in immunoblot assays. The intent was to determine if …
by using polyclonal rabbit immune sera in immunoblot assays. The intent was to determine if …
[HTML][HTML] Detecting expression of 5T4 in CTCs and tumor samples from NSCLC patients
…, E Tucker, D Marrinucci, HP Gerber, EL Powell - PLoS …, 2017 - journals.plos.org
The fetal oncogene 5T4 is a cell surface protein, with overexpression observed in a variety
of cancers as compared to normal adult tissue. The ability to select patients with tumors that …
of cancers as compared to normal adult tissue. The ability to select patients with tumors that …
Protein tyrosine kinase 7 (PTK7) biomarker analysis in patients (pts) treated with PF-06647020, a PTK7 antibody-drug conjugate (ADC), in a phase I dose expansion …
…, P Vizcarra, S Deng, S McComish, X Xin, EL Powell - Cancer Research, 2019 - AACR
Background: PF-06647020, an ADC comprising a humanized monoclonal antibody against
PTK7, a cleavable valine-citrulline linker, and an auristatin payload, is being investigated in …
PTK7, a cleavable valine-citrulline linker, and an auristatin payload, is being investigated in …