Xenograft studies indicate that some solid tumors and leukemias are organized as cellular
hierarchies sustained by cancer stem cells (CSCs). Despite the promise of the CSC model, its …

We have demonstrated previously that local, adenoviral-mediated gene transfer of viral IL-10
to a single joint of rabbits and mice with experimental arthritis can suppress disease in both …

The nonobese diabetic/severe combined immune deficiency (NOD-scid) xenotransplantation
model is the “gold standard” for assaying human hematopoietic stem cell activity. …

To investigate miRNA function in human acute myeloid leukemia (AML) stem cells (LSC),
we generated a prognostic LSC-associated miRNA signature derived from functionally …

We previously have demonstrated the ability of primary murine bone marrow-derived DC (BM-DC),
genetically modified by adenoviral infection to express FasL, to inhibit progression of …

Lifelong blood cell production is governed through the poorly understood integration of cell-intrinsic
and -extrinsic control of hematopoietic stem cell (HSC) quiescence and activation. …

Adenoviral vectors were used to deliver genes encoding a soluble interleukin 1 (IL-1)-type I
receptor-IgG fusion protein and/or a soluble type I tumor necrosis factor α (TNFα) receptor-…

Current treatments for acute myeloid leukemia (AML) are often ineffective in eliminating
leukemic stem cells (LSCs), which perpetuate the disease. Here, we performed a metabolic drug …

To investigate the pathophysiologic effects of chronically elevated intra-articular levels of IL-1
beta, we used an ex vivo gene transfer method to deliver and express human IL-1 beta (hIL…

The hematopoietic system sustains regeneration throughout life by balancing self-renewal
and differentiation. To stay poised for mature blood production, hematopoietic stem cells (…