User profiles for Eric Schadt
Eric SchadtProfessor of Genetics and Genomic Sciences, Mount Sinai School of Medicine Verified email at mssm.edu Cited by 198955 |
An integrative genomics approach to infer causal associations between gene expression and disease
A key goal of biomedical research is to elucidate the complex network of gene interactions
underlying complex traits such as common human diseases. Here we detail a multistep …
underlying complex traits such as common human diseases. Here we detail a multistep …
Genetics of gene expression surveyed in maize, mouse and man
EE Schadt, SA Monks, TA Drake, AJ Lusis, N Che… - Nature, 2003 - nature.com
Treating messenger RNA transcript abundances as quantitative traits and mapping gene
expression quantitative trait loci for these traits has been pursued in gene-specific ways. …
expression quantitative trait loci for these traits has been pursued in gene-specific ways. …
Large-scale proteomic analysis of Alzheimer's disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and …
Our understanding of Alzheimer’s disease (AD) pathophysiology remains incomplete. Here
we used quantitative mass spectrometry and coexpression network analysis to conduct the …
we used quantitative mass spectrometry and coexpression network analysis to conduct the …
A window into third-generation sequencing
EE Schadt, S Turner, A Kasarskis - Human molecular genetics, 2010 - academic.oup.com
First- and second-generation sequencing technologies have led the way in revolutionizing
the field of genomics and beyond, motivating an astonishing number of scientific advances, …
the field of genomics and beyond, motivating an astonishing number of scientific advances, …
Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease
Crohn’s disease and ulcerative colitis, the two common forms of inflammatory bowel disease
(IBD), affect over 2.5 million people of European ancestry, with rising prevalence in other …
(IBD), affect over 2.5 million people of European ancestry, with rising prevalence in other …
[HTML][HTML] An integrated map of structural variation in 2,504 human genomes
…, M Pendleton, A Quitadamo, B Raeder, EE Schadt… - Nature, 2015 - nature.com
Structural variants are implicated in numerous diseases and make up the majority of varying
nucleotides among human genomes. Here we describe an integrated set of eight structural …
nucleotides among human genomes. Here we describe an integrated set of eight structural …
[HTML][HTML] An inflammatory cytokine signature predicts COVID-19 severity and survival
Several studies have revealed that the hyper-inflammatory response induced by severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a major cause of disease severity …
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a major cause of disease severity …
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease
We performed a meta-analysis of 14 genome-wide association studies of coronary artery
disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of …
disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of …
Large-scale association analysis identifies new risk loci for coronary artery disease
Coronary artery disease (CAD) is the commonest cause of death. Here, we report an
association analysis in 63,746 CAD cases and 130,681 controls identifying 15 loci reaching …
association analysis in 63,746 CAD cases and 130,681 controls identifying 15 loci reaching …
[HTML][HTML] Bayesian test for colocalisation between pairs of genetic association studies using summary statistics
Genetic association studies, in particular the genome-wide association study (GWAS)
design, have provided a wealth of novel insights into the aetiology of a wide range of human …
design, have provided a wealth of novel insights into the aetiology of a wide range of human …