We established a collection of 7,000 transgenic lines of Drosophila melanogaster. Expression
of GAL4 in each line is controlled by a different, defined fragment of genomic DNA that …

The neural circuits responsible for animal behavior remain largely unknown. We summarize
new methods and present the circuitry of a large fraction of the brain of the fruit fly …

Drosophila melanogaster has a rich repertoire of innate and learned behaviors. Its 100,000-neuron
brain is a large but tractable target for comprehensive neural circuit mapping. Only …

The endoplasmic reticulum (ER) forms a dynamic network that contacts other cellular
membranes to regulate stress responses, calcium signalling and lipid transfer. Here, using high-…

10.7554/eLife.06694.001 Behavioral strategies employed for chemotaxis have been described
across phyla, but the sensorimotor basis of this phenomenon has seldom been studied in …

To the Editor—Recent technological developments, such as high-throughput imaging and
sequencing, enable experimentalists to collect increasingly large, complex, and …

Animal behavior is principally expressed through neural control of muscles. Therefore
understanding how the brain controls behavior requires mapping neuronal circuits all the way to …

Serial-section electron microscopy (ssEM) is the method of choice for studying macroscopic
biological samples at extremely high resolution in three dimensions. In the nervous system, …

The reconstruction of neural circuits from serial section electron microscopy (ssEM) images
is being accelerated by automatic image segmentation methods. Segmentation accuracy is …

The endoplasmic reticulum (ER) forms a dynamic network that contacts other cellular
membranes to regulate stress responses, calcium signaling, and lipid transfer. Using high-…