The nuclear expression and action of the nuclear factor kappa B (NF-κB) transcription factor
requires signal-coupled phosphorylation and degradation of the IκB inhibitors, which …

Concentrations of acetyl–coenzyme A and nicotinamide adenine dinucleotide (NAD + )
affect histone acetylation and thereby couple cellular metabolic status and transcriptional …

The silent information regulator 2 protein (Sir2p) of Saccharomyces cerevisiae is an NAD-dependent
histone deacetylase that plays a critical role in transcriptional silencing. Here, we …

For several decades, understanding ageing and the processes that limit lifespan have
challenged biologists. Thirty years ago, the biology of ageing gained unprecedented scientific …

Tauopathies, including frontotemporal dementia (FTD) and Alzheimer's disease (AD), are
neurodegenerative diseases in which tau fibrils accumulate. Recent evidence supports …

Although intermittent increases in inflammation are critical for survival during physical injury
and infection, recent research has revealed that certain social, environmental and lifestyle …

Sirtuins are NAD + -dependent protein deacetylases. They mediate adaptive responses to a
variety of stresses, including calorie restriction and metabolic stress. Sirtuin 3 (SIRT3) is …

A major cause of aging and numerous diseases is thought to be cumulative oxidative stress,
resulting from the production of reactive oxygen species (ROS) during respiration. Calorie …

Homologs of the Saccharomyces cerevisiae Sir2 protein, sirtuins, promote longevity in many
organisms. Studies of the sirtuin SIRT3 have so far been limited to cell culture systems. Here…

Acetylation is increasingly recognized as an important metabolic regulatory posttranslational
protein modification, yet the metabolic consequence of mitochondrial protein …