Vaccines work largely by generating long-lived plasma cells (LLPCs), but knowledge of how
such cells are recruited is sparse. Although it is clear that LLPCs preferentially originate in …

Maintenance of mitochondrial protein homeostasis is critical for proper cellular function.
Under normal conditions resident molecular chaperones and proteases maintain protein …

The transcription factor interferon regulatory factor 4 (IRF4) is critical for the development,
maintenance, and function of plasma cells. The mechanism by which IRF4 exerts its action in …

Systemic lupus erythematosus (SLE) is a progressive autoimmune disease characterized by
increased sensitivity to self-antigens, auto-antibody production, and systemic inflammation. …

AB cell culture system using BAFF , IL ‐4 and IL ‐21 was recently developed that generates
B cells with phenotypic and functional characteristics of in vivo‐generated germinal center (…

The maintenance of mitochondrial protein homeostasis (proteostasis) is crucial for correct
cellular function. Recently, several mutations in the mitochondrial protease CLPP have been …

Over a decade ago Polymerase δ interacting protein of 38 kDa (PDIP38) was proposed to
play a role in DNA repair. Since this time, both the physiological function and subcellular …

Polymerase δ interacting protein of 38 kDa (PDIP38) was originally identified in a yeast two
hybrid screen as an interacting protein of DNA polymerase delta, more than a decade ago. …

Submission note: This thesis is submitted in total fulfilment of the requirements for the
degree of Doctor of Philosophy to the Department of Biochemistry and Genetics, School of …

The Geographic Mosaic Theory of Coevolution predicts that coevolutionary arms races will
vary over time and space because of the diverse ecological settings and population histories …