The long-tailed macaque, also referred to as cynomolgus monkey (Macaca fascicularis), is
one of the most important nonhuman primate animal models in basic and applied biomedical …

The safety of most human recombinant proteins can be evaluated in transgenic mice
tolerant to specific human proteins. However, owing to insufficient genetic diversity and to …

Background Theileria parva is a tick-borne protozoan parasite, which causes East Coast
Fever, a disease of cattle in sub-Saharan Africa. Like Plasmodium falciparum, the parasite …

In the pharmaceutical industry, knowledge of the three-dimensional structure of a specific
target facilitates the drug-discovery process. Despite possessing favoured analytical properties …

Today, novel therapeutics are identified in an environment which is intrinsically different from
the clinical context in which they are ultimately evaluated. Using molecular phenotyping …

Background In clinical and basic research custom panels for transcript profiling are gaining
importance because only project specific informative genes are interrogated. This approach …

Bis(allyloxy)(diisopropylamino)phosphine is a new phosphinylating agent which can be
employed for an effective phosphorylation of hydroxy functions after activation by tetrazole …

Background The phenotype of a living cell is determined by its pattern of active signaling
networks, giving rise to a “molecular phenotype” associated with differential gene expression. …

Current animal-free methods to assess teratogenicity of drugs under development still
deliver high numbers of false negatives. To improve the sensitivity of human teratogenicity …

Almost 50% of cutaneous B-cell lymphoproliferative infiltrates are derived from follicular
center cells. Among these, about 25% show a rapidly progressive course, whereas about 75% …