Hypokalemic periodic paralysis (HypoPP) is a familial skeletal muscle disorder that presents
with recurrent episodes of severe weakness lasting hours to days associated with reduced …

The skeletal muscle Ca 2+ release channel, also known as ryanodine receptor type 1 (RyR1),
is the largest ion channel protein known and is crucial for effective skeletal muscle …

S100A1, a 21-kDa dimeric Ca 2+ -binding protein, is an enhancer of cardiac Ca 2+ release
and contractility and a potential therapeutic agent for the treatment of cardiomyopathy. The …

We investigated which subtypes of G-protein β subunits participate in voltage-dependent
modulation of N-type calcium channels. Calcium currents were recorded from cultured rat …

Antagonistic pleiotropy is a foundational theory that predicts aging-related diseases are the
result of evolved genetic traits conferring advantages early in life. Here we examine CaMKII, …

The process by which muscle fiber electrical depolarization is linked to activation of muscle
contraction is known as excitation-contraction coupling (ECC). Our understanding of ECC …

Objective— Mutations affecting contractile-related proteins in the ECM (extracellular matrix),
microfibrils, or vascular smooth muscle cells can predispose the aorta to aneurysms. We …

The release of Ca 2+ ions from the sarcoplasmic reticulum through ryanodine receptor
calcium release channels represents the critical step linking electrical excitation to muscular …

Ca 2+ influx through high-voltage-activated calcium channels (HVACCs) controls diverse
cellular functions. A critical feature enabling a singular signal, Ca 2+ influx, to mediate …

Skeletal muscle excitation–contraction (E–C) 1 coupling is a process composed of multiple
sequential stages, by which an action potential triggers sarcoplasmic reticulum (SR) 2 Ca 2+ …