Plasma concentrations of total cholesterol, low-density lipoprotein cholesterol, high-density
lipoprotein cholesterol and triglycerides are among the most important risk factors for …

Stroke has multiple etiologies, but the underlying genes and pathways are largely unknown.
We conducted a multiancestry genome-wide-association meta-analysis in 521,612 …

Levels of circulating glucose are tightly regulated. To identify new loci influencing glycemic
traits, we performed meta-analyses of 21 genome-wide association studies informative for …

To extend understanding of the genetic architecture and molecular basis of type 2 diabetes (T2D),
we conducted a meta-analysis of genetic variants on the Metabochip, including …

Background High plasma HDL cholesterol is associated with reduced risk of myocardial
infarction, but whether this association is causal is unclear. Exploiting the fact that genotypes are …

Background Obesity is associated with vitamin D deficiency, and both are areas of active
public health concern. We explored the causality and direction of the relationship between …

High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease.
We report the largest genetic association study of blood pressure traits (systolic, diastolic …

We propose a method (GREML-LDMS) to estimate heritability for human complex traits in
unrelated individuals using whole-genome sequencing data. We demonstrate using …

ContextDiabetes and obesity are established risk factors for congestive heart failure (CHF)
and are both associated with insulin resistance.ObjectiveTo explore if insulin resistance may …

Background— Vitamin D receptors have a broad tissue distribution that includes vascular
smooth muscle, endothelium, and cardiomyocytes. A growing body of evidence suggests that …