Parallels between T cell kinetics in mice and men have fueled the idea that a young mouse
is a good model system for a young human, and an old mouse, for an elderly human. By …

Life-long hematopoiesis depends on the support of mesenchymal stromal cells within the
bone marrow. Therefore, changes in the hematopoietic compartment that occur during …

Neutrophils are short-lived blood cells that play a critical role in host defense against infections.
To better comprehend neutrophil functions and their regulation, we provide a complete …

IL-17A, a major proinflammatory cytokine, can be produced by a variety of leukocytes, but its
exact cellular source in human inflammatory diseases remains incompletely understood. IL-…

Myeloid-derived suppressor cells (MDSCs) have the capacity to suppress T-cell–mediated
immune responses and impact the clinical outcome of cancer, infections, and transplantation …

Tissue-resident macrophages in the spleen play a major role in the clearance of immunoglobulin
G (IgG)–opsonized blood cells, as occurs in immune thrombocytopenia (ITP) and …

Background: Patients affected by different types of autoimmune diseases, including common
conditions such as multiple sclerosis (MS) and rheumatoid arthritis (RA), are often treated …

Whereas, neutrophils have long been considered to mainly function as efficient innate immunity
killers of micro-organisms at infected sites, they are now recognized to also be involved …

Background During transendothelial migration, leukocytes use adhesion molecules, such as
ICAM-1, to adhere to the endothelium. ICAM-1 is a dynamic molecule that is localized in the …

In the initial stages of transendothelial migration, leukocytes use the endothelial integrin ligands
ICAM-1 and VCAM-1 for strong adhesion. Upon adhesion of the leukocyte to endothelial …