Cancer represents a pathological manifestation of uncontrolled cell division; therefore, it
has long been anticipated that our understanding of the basic principles of cell cycle control …

Pancreatic ductal adenocarcinoma (PDA) has a dismal prognosis and insights into both
disease etiology and targeted intervention are needed. A total of 109 micro-dissected PDA …

In animal cells, duplication of centrosomes and DNA is coordinated. Since CDK2/cyclin E
triggers initiation of both events, activation of CDK2/cyclin E is thought to link these two events. …

Pancreatic ductal adenocarcinoma (PDAC) is characterized by KRAS- and autophagy-dependent
tumorigenic growth, but the role of KRAS in supporting autophagy has not been …

The retinoblastoma tumour suppressor (RB) is a crucial regulator of cell-cycle progression
that is invoked in response to a myriad of anti-mitogenic signals. It has been hypothesized that …

Previously, we showed that high-energy metabolites (lactate and ketones) “fuel” tumor growth
and experimental metastasis in an in vivo xenograft model, most likely by driving oxidative …

Polyhalogenated aromatic hydrocarbons, of which 2,3,7,8-tetrachloro-p-dioxin (TCDD) is
the prototype compound, elicit a variety of toxic, teratogenic, and carcinogenic responses in …

Retinoblastoma (RB; encoded by RB1) is a tumor suppressor that is frequently disrupted in
tumorigenesis and acts in multiple cell types to suppress cell cycle progression. The role of …

The retinoblastoma tumor suppressor protein, RB, contains at least three distinct protein
binding domains. The A/B pocket binds proteins with the LXCXE motif, the C pocket binds the …

The majority of estrogen receptor (ER)-positive breast cancers are treated with endocrine
therapy. While this is effective, acquired resistance to therapies targeted against ER is a major …