A genetically encoded fluorescent sensor for in vivo imaging of GABA

…, M Leite, T Kawashima, TP Jensen, I Kolb, EL Knott… - Nature …, 2019 - nature.com
Current techniques for monitoring GABA (γ-aminobutyric acid), the primary inhibitory
neurotransmitter in vertebrates, cannot follow transients in intact neural circuits. To develop a GABA …

Determination of an effective housekeeping gene for the quantification of mRNA for forensic applications

LI Moreno, CM Tate, EL Knott… - Journal of Forensic …, 2012 - Wiley Online Library
The potential application of mRNA for the identification of biological fluids using molecular
techniques has been a recent development in forensic serology. Constitutively expressed …

[HTML][HTML] A targeted bioinformatics assessment of adrenocortical carcinoma reveals prognostic implications of GABA system gene expression

EL Knott, NJ Leidenheimer - International journal of molecular sciences, 2020 - mdpi.com
Adrenocortical carcinoma (ACC) is a rare but deadly cancer for which few treatments exist.
Here, we have undertaken a targeted bioinformatics study of The Cancer Genome Atlas (…

The role of the GABA shunt in prostate cancer metabolic reprogramming and aggressive phenotype

EL Knott, S Miriyala, H Nam, M Panchatcharam… - Cancer Research, 2018 - AACR
The GABA (γ-aminobutyric acid) shunt, a bypass mechanism for a portion of the tricarboxylic
acid (TCA) cycle, is responsible in the mammalian central nervous system for the synthesis …

Targeted bioinformatics analysis identifies high ABAT transcript expression as a multi-cancer marker of favorable patient prognosis

EL Knott, NJ Leidenheimer - Cancer Research, 2021 - AACR
Unsupervised analysis of γ-aminobutyric acid (GABA) system genes has identified some
genes as correlated with indicators of severity in several cancers. Central to GABA system …

Prostate cancer cells utilize the GABA shunt to enhance oxidative metabolism

EL Knott, S Miriyala, M Panchatcharam… - Cancer Research, 2019 - AACR
Although an upregulation of aerobic glycolysis (the Warburg effect) is a canonical hallmark
of cancer, it is now recognized that most cancerous cells continue to rely on the TCA cycle as …

[HTML][HTML] The HEALing (Helping to End Addiction Long-term SM) Communities Study: Protocol for a cluster randomized trial at the community level to reduce opioid …

…, T Hunt, A Hyder, R Kerner, K Keyes, CE Knott… - Drug and alcohol …, 2020 - Elsevier
Background Opioid overdose deaths remain high in the US Despite having effective interventions
to prevent overdose deaths, there are numerous barriers that impede their adoption. …

GABA system expression level changes persist across cancers of many organ systems

EL Knott, NJ Leidenheimer - Cancer Research, 2020 - AACR
Erika Lynn Knott; Erika Lynn Knott … Citation Format: Erika Lynn Knott, Nancy J. Leidenheimer.
GABA system expression level changes persist across cancers of many organ systems […

Assortative mating and mate‐choice contributes to the maintenance of a developmental dimorphism in Streblospio benedicti

EL Ruskie, C Zakas - Journal of Experimental Zoology Part B …, 2023 - Wiley Online Library
Erika L. Ruskie was responsible for data collection and analysis as well as writing the
original draft. She received an Office of Undergraduate Research Award from NCSU (Summer …

Resident TH2 cells orchestrate adipose tissue remodeling at a site adjacent to infection

…, JD Curtis, A Castoldi, J Cupovic, L Dreesen… - Science …, 2022 - science.org
Type 2 immunity is associated with adipose tissue (AT) homeostasis and infection with
parasitic helminths, but whether AT participates in immunity to these parasites is unknown. We …