The current methods available to diagnose antimicrobial-resistant Mycobacterium
tuberculosis infections require a positive culture or only test a limited number of resistance-associated …

Norovirus full-genome sequencing is challenging due to sequence heterogeneity among
genomes. Previous methods have relied on PCR amplification, which is problematic due to …

Favipiravir for Chronic Norovirus Infection Norovirus may cause chronic diarrhea, especially
in immunosuppressed patients. There is no established treatment. In this case report, …

Background Adenoviruses are significant pathogens for the immunocompromised, arising
from primary infection or reinfection. Serotyping is insufficient to support nosocomial …

DIPG are characterised by histone H3K27M mutations, resulting in global loss of the repressive
mark H3K27me3, although certain key loci are retained. We recently identified subclonal …

Genetic screens provide a mechanism to identify genes involved with different cellular and
organismal processes. Using a Flp/FRT screen in the Drosophila eye we identified mutations …

Background Studying within-host genetic diversity of Mycobacterium tuberculosis (Mtb) in
patients during treatment may identify adaptations to antibiotic and immune pressure. …

Enrichment of DNA by hybridisation is an important tool which enables users to gather target-focused
next-generation sequence data in an economical fashion. Current in-solution …

Whole-genome sequencing of pathogenic organisms directly from clinical samples combines
detection and genotyping in one step. This can speed up diagnosis, especially for slow-…

Background: Adenoviruses are significant pathogens for the immunocompromised, arising
from primary infection or reinfection. Serotyping is insufficient to support nosocomial …